PMID- 17418416
OWN - NLM
STAT- MEDLINE
DCOM- 20070816
LR  - 20191210
IS  - 0149-7634 (Print)
IS  - 0149-7634 (Linking)
VI  - 31
IP  - 4
DP  - 2007
TI  - Relevance to self: A brief review and framework of neural systems underlying 
      appraisal.
PG  - 585-96
AB  - We argue that many similar findings observed in cognitive, affective, and social 
      neuroimaging research may compose larger processes central to generating 
      self-relevance. In support of this, recent findings from these research domains 
      were reviewed to identify common systemic activation patterns. Superimposition of 
      these patterns revealed evidence for large-scale supramodal processes, which are 
      argued to mediate appraisal of self-relevant content irrespective of specific 
      stimulus types (e.g. words, pictures) and task domains (e.g. induction of reward, 
      fear, pain, etc.). Furthermore, we distinguish between two top-down sub-systems 
      involved in appraisal of self-relevance, one that orients pre-attentive biasing 
      information (e.g. anticipatory or mnemonic) to salient or explicitly 
      self-relevant phenomena, and another that engages introspective processes (e.g. 
      self-reflection, evaluation, recollection) either in conjunction with or 
      independent of the former system. Based on aggregate patterns of activation 
      derived from the reviewed studies, processes in a ventral medial prefrontal 
      cortex (MPFC)-subcortical network appear to track with the former pathway, and 
      processes in a dorsal MPFC-cortical-subcortical network with the latter. As a 
      whole, the purpose of this framework is to re-conceive the functionality of these 
      systems in terms of supramodal processes that more directly reflect the 
      influences of relevance to the self.
FAU - Schmitz, Taylor W
AU  - Schmitz TW
AD  - William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA. 
      taylor.schmitz@utoronto.ca
FAU - Johnson, Sterling C
AU  - Johnson SC
LA  - eng
GR  - R01 MH065723-04/MH/NIMH NIH HHS/United States
GR  - R01 MH065723-05/MH/NIMH NIH HHS/United States
GR  - R01 MH065723/MH/NIMH NIH HHS/United States
GR  - R01 AG021155/AG/NIA NIH HHS/United States
GR  - R01 MH65723/MH/NIMH NIH HHS/United States
GR  - R01 MH065723-06/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - Neurosci Biobehav Rev
JT  - Neuroscience and biobehavioral reviews
JID - 7806090
SB  - IM
MH  - *Brain Mapping
MH  - Cerebral Cortex/*physiology
MH  - Ego
MH  - Humans
MH  - Introversion, Psychological
MH  - *Models, Neurological
MH  - *Neural Pathways
MH  - *Self Concept
PMC - PMC1973156
MID - NIHMS25399
EDAT- 2007/04/10 09:00
MHDA- 2007/08/19 09:00
PMCR- 2007/09/07
CRDT- 2007/04/10 09:00
PHST- 2006/04/04 00:00 [received]
PHST- 2006/09/29 00:00 [revised]
PHST- 2006/12/30 00:00 [accepted]
PHST- 2007/04/10 09:00 [pubmed]
PHST- 2007/08/19 09:00 [medline]
PHST- 2007/04/10 09:00 [entrez]
PHST- 2007/09/07 00:00 [pmc-release]
AID - S0149-7634(07)00005-X [pii]
AID - 10.1016/j.neubiorev.2006.12.003 [doi]
PST - ppublish
SO  - Neurosci Biobehav Rev. 2007;31(4):585-96. doi: 10.1016/j.neubiorev.2006.12.003.