PMID- 17421024
OWN - NLM
STAT- MEDLINE
DCOM- 20070907
LR  - 20131121
IS  - 1050-9631 (Print)
IS  - 1050-9631 (Linking)
VI  - 17
IP  - 7
DP  - 2007
TI  - Influence of age on BDNF modulation of hippocampal synaptic transmission: 
      interplay with adenosine A2A receptors.
PG  - 577-85
AB  - We previously reported that adenosine, through A(2A) receptor activation, 
      potentiates synaptic actions of brain-derived neurotrophic factor (BDNF) in the 
      hippocampus of infant (3-4 weeks) rats. Since A(2A)-receptor-mediated actions are 
      more evident in old than in young rats and since the therapeutic potential for 
      BDNF-based strategies is greater in old subjects, we now evaluated synaptic 
      actions of BDNF and the levels of TrkB receptors and of adenosine A(2A) receptors 
      in the hippocampus of three groups of adult rats: young adults (10-16 weeks), old 
      adults (36-38 weeks), and aged (70-80 weeks), as well as in one group of infant 
      (3-4 weeks) rats. BDNF (20 ng/ml) enhances field excitatory postsynaptic 
      potentials recorded from the hippocampus of young adults and aged rats, an action 
      triggered by adenosine A(2A) receptor activation, since it was blocked by the 
      A(2A) receptor antagonist, ZM 241385. In the other groups of animals BDNF (20 
      ng/ml) was virtually devoid of action on synaptic transmission. Western blot 
      analysis of receptor density shows decreased amounts of TrkB receptors in old 
      adults and aged rats, whereas A(2A) receptor levels assayed by ligand binding are 
      enhanced in the hippocampus of old adults and aged rats. It is concluded that 
      age-related changes in the density of TrkB receptors and of adenosine A(2A) 
      receptors may be responsible for a nonmonotonous variation of BDNF actions on 
      synaptic transmission in the hippocampus.
CI  - (c) 2007 Wiley-Liss, Inc.
FAU - Diogenes, Maria J
AU  - Diogenes MJ
AD  - Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of 
      Lisbon, Lisbon, Portugal.
FAU - Assaife-Lopes, Natalia
AU  - Assaife-Lopes N
FAU - Pinto-Duarte, Antonio
AU  - Pinto-Duarte A
FAU - Ribeiro, Joaquim A
AU  - Ribeiro JA
FAU - Sebastiao, Ana M
AU  - Sebastiao AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hippocampus
JT  - Hippocampus
JID - 9108167
RN  - 0 (Adenosine A2 Receptor Agonists)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptor, Adenosine A2A)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - K72T3FS567 (Adenosine)
SB  - IM
MH  - Adenosine/metabolism
MH  - Adenosine A2 Receptor Agonists
MH  - Aging/*physiology
MH  - Animals
MH  - Binding, Competitive/physiology
MH  - Brain-Derived Neurotrophic Factor/*metabolism/pharmacology
MH  - Down-Regulation/drug effects/physiology
MH  - Excitatory Postsynaptic Potentials/drug effects/physiology
MH  - Hippocampus/drug effects/*growth & development/*metabolism
MH  - Male
MH  - Neural Pathways/drug effects/growth & development/metabolism
MH  - Organ Culture Techniques
MH  - Presynaptic Terminals/metabolism
MH  - Radioligand Assay
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, Adenosine A2A/*metabolism
MH  - Receptor, trkB/agonists/metabolism
MH  - Synaptic Transmission/drug effects/*physiology
MH  - Up-Regulation/drug effects/physiology
EDAT- 2007/04/11 09:00
MHDA- 2007/09/08 09:00
CRDT- 2007/04/11 09:00
PHST- 2007/04/11 09:00 [pubmed]
PHST- 2007/09/08 09:00 [medline]
PHST- 2007/04/11 09:00 [entrez]
AID - 10.1002/hipo.20294 [doi]
PST - ppublish
SO  - Hippocampus. 2007;17(7):577-85. doi: 10.1002/hipo.20294.