PMID- 17425385
OWN - NLM
STAT- MEDLINE
DCOM- 20070712
LR  - 20210527
IS  - 1543-2165 (Electronic)
IS  - 0003-9985 (Linking)
VI  - 131
IP  - 4
DP  - 2007 Apr
TI  - Serum levels of matrix metalloproteinase 3 (stromelysin 1) for monitoring 
      synovitis in rheumatoid arthritis.
PG  - 563-70
AB  - CONTEXT: Matrix metalloproteinase 3 (MMP-3) is expressed in synovial tissues and 
      involved in cartilage destruction in rheumatoid arthritis and osteoarthritis. 
      OBJECTIVE: To study whether measurement of MMP-3 serum concentrations is useful 
      to monitor the activity of rheumatoid synovitis. DESIGN: Levels of MMP-3 in serum 
      and synovial tissue samples obtained from 29 rheumatoid arthritis patients and 20 
      osteoarthritis patients were measured by the 1-step sandwich enzyme immunoassay 
      system. RESULTS: Levels of MMP-3 in the serum and synovial samples were 
      significantly higher in rheumatoid arthritis than in osteoarthritis (P < .001), 
      and the levels correlated directly with each other (r = 0.712, P < .001; N = 49). 
      Immunohistochemistry demonstrated almost exclusive localization of MMP-3 to the 
      lining cells in rheumatoid synovium. The immunoreactivity correlated directly 
      with the scores of synovial inflammatory cell infiltration (r = 0.606, P < .001; 
      n = 29) and the MMP-3 levels in the synovial tissues (r = 0.564, P = .001; n = 
      29) and those in the serum samples (r = 0.529, P = .003; n = 29) in rheumatoid 
      arthritis. Levels of MMP-3 in rheumatoid serum samples dropped to low values at 1 
      and 2 weeks after total knee arthroplasty, while the levels of C-reactive protein 
      increased at 1 week and the erythrocyte sedimentation rate and counts of white 
      blood cells and platelets were unchanged at 1 and 2 weeks postoperative. 
      CONCLUSIONS: Our results demonstrate that MMP-3 levels in the serum of rheumatoid 
      arthritis patients correlate with the levels produced by the synovial lining 
      cells and suggest that the activity of rheumatoid synovitis can be monitored by 
      measuring serum levels of MMP-3.
FAU - Kobayashi, Ari
AU  - Kobayashi A
AD  - Department of Pathology, School of Medicine, Keio University, Tokyo, Japan.
FAU - Naito, Satoko
AU  - Naito S
FAU - Enomoto, Hiroyuki
AU  - Enomoto H
FAU - Shiomoi, Takayuki
AU  - Shiomoi T
FAU - Kimura, Tokuhiro
AU  - Kimura T
FAU - Obata, Ken'ichi
AU  - Obata K
FAU - Inoue, Kazuhiko
AU  - Inoue K
FAU - Okada, Yasunori
AU  - Okada Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Pathol Lab Med
JT  - Archives of pathology & laboratory medicine
JID - 7607091
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Aged
MH  - Arthritis, Rheumatoid/*blood/complications
MH  - Arthroplasty, Replacement, Knee
MH  - Female
MH  - Humans
MH  - Immunoassay
MH  - Immunohistochemistry
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood
MH  - Middle Aged
MH  - Osteoarthritis, Knee/blood
MH  - Synovitis/*blood/etiology
EDAT- 2007/04/12 09:00
MHDA- 2007/07/13 09:00
CRDT- 2007/04/12 09:00
PHST- 2006/09/12 00:00 [accepted]
PHST- 2007/04/12 09:00 [pubmed]
PHST- 2007/07/13 09:00 [medline]
PHST- 2007/04/12 09:00 [entrez]
AID - OA6-0408 [pii]
AID - 10.5858/2007-131-563-SLOMMS [doi]
PST - ppublish
SO  - Arch Pathol Lab Med. 2007 Apr;131(4):563-70. doi: 10.5858/2007-131-563-SLOMMS.