PMID- 17426528
OWN - NLM
STAT- MEDLINE
DCOM- 20070627
LR  - 20161018
IS  - 1076-2752 (Print)
IS  - 1076-2752 (Linking)
VI  - 49
IP  - 4
DP  - 2007 Apr
TI  - TNF-alpha polymorphisms in chronic beryllium disease and beryllium sensitization.
PG  - 446-52
AB  - OBJECTIVE: Tumor necrosis factor-alpha (TNF-alpha) is a potent cytokine involved 
      in normal immune functions. The aim of this study was to investigate if there is 
      an association between chronic beryllium disease or beryllium sensitization and 
      two variants of the TNF-alpha gene located at -308 and -238 called 
      TNF-alpha-308*02 and TNF-alpha-238*02. METHODS: TNF-alpha-308 and TNF-alpha-238 
      genotyping was conducted in a large, population-based cohort consisting of 886 
      beryllium workers (92 individuals with chronic beryllium disease, 64 who were 
      beryllium sensitized, and 730 individuals without sensitization or disease). 
      RESULTS: The odds of chronic beryllium disease in the presence of at least one 
      TNF-alpha-308*02 or TNF-alpha-238*02 allele was not significant (OR=1.0; 95% 
      CI=0.7, 1.7 and OR=0.8; 95% CI=0.4, 1.6). This was true regardless of whether a 
      worker was homozygous or heterozygous for TNF-alpha-308*02 or TNF-alpha-238*02. 
      Similarly, neither allele was associated with sensitization (P>0.05). 
      CONCLUSIONS: Unlike an earlier report, there was no association between these 
      specific TNF-alpha alleles and either chronic beryllium disease or sensitization 
      to beryllium.
FAU - McCanlies, Erin C
AU  - McCanlies EC
AD  - Health Effects Laboratory Division, National Institute for Occupational Safety 
      and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 
      26505, USA. EIM4@CDC/GOV
FAU - Schuler, Christine R
AU  - Schuler CR
FAU - Kreiss, Kathleen
AU  - Kreiss K
FAU - Frye, Bonnie L
AU  - Frye BL
FAU - Ensey, James S
AU  - Ensey JS
FAU - Weston, Ainsley
AU  - Weston A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Occup Environ Med
JT  - Journal of occupational and environmental medicine
JID - 9504688
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - OW5102UV6N (Beryllium)
SB  - IM
MH  - Alleles
MH  - Berylliosis/*genetics/immunology
MH  - Beryllium/blood/immunology/*toxicity
MH  - Chronic Disease
MH  - Genotype
MH  - HLA-DP Antigens/genetics
MH  - HLA-DP beta-Chains
MH  - Humans
MH  - Hypersensitivity/etiology/*genetics
MH  - Lymphocyte Activation
MH  - Occupational Exposure/*adverse effects
MH  - *Polymorphism, Genetic
MH  - Risk Factors
MH  - Sequence Analysis, Protein
MH  - Tumor Necrosis Factor-alpha/chemistry/*genetics
MH  - United States
EDAT- 2007/04/12 09:00
MHDA- 2007/06/28 09:00
CRDT- 2007/04/12 09:00
PHST- 2007/04/12 09:00 [pubmed]
PHST- 2007/06/28 09:00 [medline]
PHST- 2007/04/12 09:00 [entrez]
AID - 00043764-200704000-00014 [pii]
AID - 10.1097/JOM.0b013e31803b9499 [doi]
PST - ppublish
SO  - J Occup Environ Med. 2007 Apr;49(4):446-52. doi: 10.1097/JOM.0b013e31803b9499.