PMID- 17426976
OWN - NLM
STAT- MEDLINE
DCOM- 20071016
LR  - 20220716
IS  - 0172-8172 (Print)
IS  - 0172-8172 (Linking)
VI  - 27
IP  - 8
DP  - 2007 Jun
TI  - Serum pro-matrix metalloproteinase-3 as an indicator of disease activity and 
      severity in rheumatoid arthritis: comparison with traditional markers.
PG  - 715-22
AB  - Matrix metalloproteinase-3 (MMP-3) production increases in rheumatoid arthritis 
      (RA) and has been proposed as a marker of disease activity and joint damage. The 
      aim of this cross-sectional study is to examine the usefulness of serum proMMP-3 
      as an indicator of disease activity and severity in comparison with erythrocyte 
      sedimentation rate (ESR) and C-reactive protein (CRP). Serum proMMP-3 was 
      measured by a quantitative ELISA in 85 RA patients and 70 healthy subjects. 
      Clinical and laboratory measures of disease activity and severity were obtained. 
      Radiological joint damage was assessed by the method of Larsen. Serum proMMP-3 
      was significantly higher in RA patients than that in the healthy subjects. The 
      active RA patients had significantly higher serum proMMP-3 than the inactive 
      patients. Serum proMMP-3 was significantly correlated with some parameters of 
      disease activity including swollen joints count, proximal interphalangeal joint 
      score, morning stiffness, and Health Assessment Questionnaire; however, ESR and 
      serum CRP were better correlated with all indicators of the disease activity than 
      proMMP-3. The analysis of receiver operating characteristic supported that ESR 
      and CRP had higher performance for reflection of activity compared to proMMP-3. 
      There were no significant associations among Larsen score and proMMP-3, ESR, and 
      CRP. Our results suggest that the cross-sectional measurement of serum proMMP-3 
      could not give additional information about RA disease activity compared to ESR 
      and CRP, and could not give any information about joint damage.
FAU - Ates, Askin
AU  - Ates A
AD  - Department of Clinical Immunology and Rheumatology, Ankara University School of 
      Medicine, Ankara, Turkey. ates@medicine.ankara.edu.tr
FAU - Turkcapar, Nuran
AU  - Turkcapar N
FAU - Olmez, Umit
AU  - Olmez U
FAU - Tiryaki, Olcay
AU  - Tiryaki O
FAU - Duzgun, Nursen
AU  - Duzgun N
FAU - Uguz, Emre
AU  - Uguz E
FAU - Duman, Murat
AU  - Duman M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20070411
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Biomarkers)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Arthritis, Rheumatoid/*blood/classification/pathology
MH  - Biomarkers
MH  - Blood Sedimentation
MH  - C-Reactive Protein/*analysis
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood
MH  - Middle Aged
MH  - ROC Curve
MH  - Severity of Illness Index
EDAT- 2007/04/12 09:00
MHDA- 2007/10/17 09:00
CRDT- 2007/04/12 09:00
PHST- 2006/06/03 00:00 [received]
PHST- 2007/03/06 00:00 [accepted]
PHST- 2007/04/12 09:00 [pubmed]
PHST- 2007/10/17 09:00 [medline]
PHST- 2007/04/12 09:00 [entrez]
AID - 10.1007/s00296-007-0338-1 [doi]
PST - ppublish
SO  - Rheumatol Int. 2007 Jun;27(8):715-22. doi: 10.1007/s00296-007-0338-1. Epub 2007 
      Apr 11.