PMID- 17427185 OWN - NLM STAT- MEDLINE DCOM- 20070814 LR - 20221207 IS - 1552-4841 (Print) IS - 1552-4841 (Linking) VI - 144B IP - 4 DP - 2007 Jun 5 TI - Nuclear receptor NR4A2 IVS6 +18insG and brain derived neurotrophic factor (BDNF) V66M polymorphisms and risk of Taiwanese Parkinson's disease. PG - 458-62 AB - Both of environmental and genetic factors confer vulnerability to Parkinson's disease (PD). NR4A2 (Nurr1), a member of the steroid/thyroid hormone nuclear receptor superfamily, is essential for the neurogenesis and differentiation of dopaminergic neurons in the midbrain. Brain derived neurotrophic factor (BDNF) deficiency may play a role in the pathogenesis of PD, as the surviving dopaminergic nigrostriatal neurons have reduced levels of BDNF. This study examines whether BDNF V66M (c.196 G --> A) or NR4A2 IVS6 +18insG polymorphism is associated with the risk of Taiwanese PD and the age of onset using a case-control study. The genotype or allele frequency distribution of both BDNF V66M and NR4A2 IVS6 +18insG polymorphisms was not significantly different between the cases and the controls. Neither BDNF nor NR4A2 polymorphism influences PD onset age. Notably, after stratification by sex, female individuals carrying the NR4A2 2G/2G genotype demonstrated a trend toward significant decrease in risk of developing PD (OR = 0.49, 95% CI = 0.25-0.96, P = 0.039). These results suggest that the NR4A2 IVS6 +18insG polymorphism may play a minor role in PD susceptibility among Taiwanese women. CI - (c) 2007 Wiley-Liss, Inc. FAU - Chen, Chiung-Mei AU - Chen CM AD - Department of Neurology, Chang Gung Memorial Hospital, Chang-Gung University College of Medicine, Taipei, Taiwan. FAU - Chen, I-Cheng AU - Chen IC FAU - Chang, Kuo-Hsuan AU - Chang KH FAU - Chen, Yi-Chun AU - Chen YC FAU - Lyu, Rong-Kuo AU - Lyu RK FAU - Liu, Yen-Tzu AU - Liu YT FAU - Hu, Fen-Ju AU - Hu FJ FAU - Chao, Chih-Ying AU - Chao CY FAU - Lee-Chen, Guey-Jen AU - Lee-Chen GJ FAU - Wu, Yih-Ru AU - Wu YR LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Am J Med Genet B Neuropsychiatr Genet JT - American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics JID - 101235742 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (DNA-Binding Proteins) RN - 0 (NR4A2 protein, human) RN - 0 (Nuclear Receptor Subfamily 4, Group A, Member 2) RN - 0 (Transcription Factors) RN - AE28F7PNPL (Methionine) RN - HG18B9YRS7 (Valine) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Asian People/*genetics MH - Brain-Derived Neurotrophic Factor/*genetics MH - Case-Control Studies MH - DNA-Binding Proteins/*genetics MH - Female MH - Genetic Predisposition to Disease MH - Humans MH - Male MH - Methionine/*genetics MH - Middle Aged MH - Nuclear Receptor Subfamily 4, Group A, Member 2 MH - Parkinson Disease/*genetics MH - *Polymorphism, Genetic MH - Risk Factors MH - Sex Characteristics MH - Taiwan MH - Transcription Factors/*genetics MH - Valine/*genetics EDAT- 2007/04/12 09:00 MHDA- 2007/08/19 09:00 CRDT- 2007/04/12 09:00 PHST- 2007/04/12 09:00 [pubmed] PHST- 2007/08/19 09:00 [medline] PHST- 2007/04/12 09:00 [entrez] AID - 10.1002/ajmg.b.30476 [doi] PST - ppublish SO - Am J Med Genet B Neuropsychiatr Genet. 2007 Jun 5;144B(4):458-62. doi: 10.1002/ajmg.b.30476.