PMID- 17428180
OWN - NLM
STAT- MEDLINE
DCOM- 20071126
LR  - 20091119
IS  - 0199-9885 (Print)
IS  - 0199-9885 (Linking)
VI  - 27
DP  - 2007
TI  - Conserved and tissue-specific genic and physiologic responses to caloric 
      restriction and altered IGFI signaling in mitotic and postmitotic tissues.
PG  - 193-217
AB  - Caloric restriction (CR), the consumption of fewer calories without malnutrition, 
      and reduced insulin and/or IGFI receptor signaling delay many age-related 
      physiological changes and extend the lifespan of many model organisms. Here, we 
      present and review microarray and biochemical studies indicating that the potent 
      anticancer effects of CR and disrupted insulin/IGFI receptor signaling evolved as 
      a byproduct of the role of many mitotic tissues as reservoirs of metabolic 
      energy. We argue that the longevity effects of CR are derived from repeated 
      cycles of apoptosis and autophagic cell death in mitotically competent tissues 
      and protein turnover and cellular repair in postmitotic tissues. We review 
      studies showing that CR initiated late in life can rapidly induce many of the 
      benefits of lifelong CR, including its anticancer effects. We also discuss 
      evidence from liver and heart indicating that many benefits of lifelong CR are 
      recapitulated in mitotic and postmitotic tissues when CR is initiated late in 
      life.
FAU - Spindler, Stephen R
AU  - Spindler SR
AD  - Department of Biochemistry, University of California, Riverside, CA 92521, USA. 
      spindler@ucr.edu
FAU - Dhahbi, Joseph M
AU  - Dhahbi JM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Annu Rev Nutr
JT  - Annual review of nutrition
JID - 8209988
RN  - EC 2.7.10.1 (Receptor, IGF Type 1)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - *Caloric Restriction
MH  - Humans
MH  - Longevity
MH  - Mice
MH  - Mitosis/*physiology
MH  - Models, Animal
MH  - Nutritional Physiological Phenomena/*physiology
MH  - Oligonucleotide Array Sequence Analysis
MH  - Receptor, IGF Type 1/metabolism/*physiology
RF  - 137
EDAT- 2007/04/13 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/04/13 09:00
PHST- 2007/04/13 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/04/13 09:00 [entrez]
AID - 10.1146/annurev.nutr.27.061406.093743 [doi]
PST - ppublish
SO  - Annu Rev Nutr. 2007;27:193-217. doi: 10.1146/annurev.nutr.27.061406.093743.