PMID- 17429039
OWN - NLM
STAT- MEDLINE
DCOM- 20070515
LR  - 20221109
IS  - 0031-9333 (Print)
IS  - 1522-1210 (Electronic)
IS  - 0031-9333 (Linking)
VI  - 87
IP  - 2
DP  - 2007 Apr
TI  - Disordered lipid metabolism and the pathogenesis of insulin resistance.
PG  - 507-20
AB  - Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM) and 
      accounts for many of its symptoms and complications, efforts to understand the 
      pathogenesis of T2DM are increasingly focused on disordered lipid metabolism. 
      Here we review recent human studies exploring the mechanistic links between 
      disorders of fatty acid/lipid metabolism and insulin resistance. As "mouse models 
      of insulin resistance" were comprehensively reviewed in Physiological Reviews by 
      Nandi et al. in 2004, we will concentrate on human studies involving the use of 
      isotopes and/or magnetic resonance spectroscopy, occasionally drawing on mouse 
      models which provide additional mechanistic insight.
FAU - Savage, David B
AU  - Savage DB
AD  - Department of Internal Medicine, Howard Hughes Medical Institute, Yale University 
      School of Medicine, New Haven, CT 06536-8012, USA.
FAU - Petersen, Kitt Falk
AU  - Petersen KF
FAU - Shulman, Gerald I
AU  - Shulman GI
LA  - eng
GR  - R01 DK049230/DK/NIDDK NIH HHS/United States
GR  - P01-DK-68829/DK/NIDDK NIH HHS/United States
GR  - R01 DK040936/DK/NIDDK NIH HHS/United States
GR  - R01 AG023686/AG/NIA NIH HHS/United States
GR  - R01-DK-49230/DK/NIDDK NIH HHS/United States
GR  - U24-DK-59635/DK/NIDDK NIH HHS/United States
GR  - WT_/Wellcome Trust/United Kingdom
GR  - M01-RR-00125/RR/NCRR NIH HHS/United States
GR  - R01-DK-40936/DK/NIDDK NIH HHS/United States
GR  - R01-AG-23686/AG/NIA NIH HHS/United States
GR  - M01 RR000125/RR/NCRR NIH HHS/United States
GR  - U24 DK059635/DK/NIDDK NIH HHS/United States
GR  - R01 AG023686-05/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Physiol Rev
JT  - Physiological reviews
JID - 0231714
RN  - 0 (Fatty Acids)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adipose Tissue/metabolism
MH  - Animals
MH  - Fatty Acids/pharmacology
MH  - Glucose/metabolism
MH  - Humans
MH  - Insulin Resistance/*physiology
MH  - Lipid Metabolism Disorders/*physiopathology
MH  - Liver/chemistry/metabolism
MH  - Magnetic Resonance Spectroscopy
MH  - Muscles/chemistry/metabolism
MH  - Obesity/metabolism
PMC - PMC2995548
MID - NIHMS251019
EDAT- 2007/04/13 09:00
MHDA- 2007/05/16 09:00
PMCR- 2010/12/01
CRDT- 2007/04/13 09:00
PHST- 2007/04/13 09:00 [pubmed]
PHST- 2007/05/16 09:00 [medline]
PHST- 2007/04/13 09:00 [entrez]
PHST- 2010/12/01 00:00 [pmc-release]
AID - 87/2/507 [pii]
AID - 10.1152/physrev.00024.2006 [doi]
PST - ppublish
SO  - Physiol Rev. 2007 Apr;87(2):507-20. doi: 10.1152/physrev.00024.2006.