PMID- 17429537
OWN - NLM
STAT- MEDLINE
DCOM- 20081222
LR  - 20181201
IS  - 1003-9279 (Print)
IS  - 1003-9279 (Linking)
VI  - 21
IP  - 1
DP  - 2007 Mar
TI  - [A clinical study on combined serum hepatic fibrosis-related markers and 
      ultrasound parameters to diagnose hepatic fibrosis].
PG  - 56-8
AB  - OBJECTIVE: This study attempted to explore the value of combining serum hepatic 
      fibrosis-related markers and ultrasound parameters together on diagnosis of 
      hepatic fibrosis. METHODS: Six serum markers and 8 ultrasound parameters were 
      measured from 100 patients with chronic hepatitis B or cirrhosis. The results of 
      the serum hepatic fibrosis-related markers and ultrasound in disease group were 
      analyzed and compared with the findings of hepatic pathology. RESULTS: By 
      filtrating,the group of platelet derived growth factor-BB (PDGF-BB) plus 
      hyaluronic acid (HA) plus echo characteristics of liver parenchyma (LPEC) plus 
      length of spleen (SL) had the highest Se and Spe, which were 90.7% and 85.4% 
      respectively. CONCLUSION: The advantageous combination of serum markers and 
      ultrasound parameters can significantly improve Se and Spe, which is superior to 
      any single serum index or ultrasound parameter. And it was a better non-invasive 
      method for diagnosing hepatic fibrosis.
FAU - Yu, Jing
AU  - Yu J
AD  - Department of the Second Internal Medicine, Henan Provincial People's Hospital, 
      Zhengzhou 450003, China.
FAU - Jia, Chang-he
AU  - Jia CH
FAU - Wang, Qi
AU  - Wang Q
FAU - Xu, Po-shi
AU  - Xu PS
FAU - Zhang, Hao
AU  - Zhang H
FAU - Zhao, Yu-qin
AU  - Zhao YQ
FAU - Shen, Quan
AU  - Shen Q
FAU - Hao, Yan-rui
AU  - Hao YR
FAU - Cai, Gui-fen
AU  - Cai GF
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
JT  - Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang 
      bingduxue zazhi = Chinese journal of experimental and clinical virology
JID - 9602873
RN  - 0 (Biomarkers)
RN  - 0 (Collagen Type III)
RN  - 0 (Platelet-Derived Growth Factor)
RN  - 0 (Proto-Oncogene Proteins c-sis)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - 0 (Transforming Growth Factor beta)
RN  - 1B56C968OA (Becaplermin)
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alanine Transaminase/blood
MH  - Becaplermin
MH  - Biomarkers/*blood
MH  - Collagen Type III/blood
MH  - Female
MH  - Hepatitis B, Chronic/blood/*diagnosis/diagnostic imaging
MH  - Humans
MH  - Hyaluronic Acid/blood
MH  - Liver Cirrhosis/blood/*diagnosis/diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Platelet-Derived Growth Factor/analysis
MH  - Proto-Oncogene Proteins c-sis
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Tissue Inhibitor of Metalloproteinase-1/blood
MH  - Transforming Growth Factor beta/blood
MH  - Ultrasonography, Doppler, Color/*methods
MH  - Young Adult
EDAT- 2007/04/13 09:00
MHDA- 2008/12/23 09:00
CRDT- 2007/04/13 09:00
PHST- 2007/04/13 09:00 [pubmed]
PHST- 2008/12/23 09:00 [medline]
PHST- 2007/04/13 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2007 Mar;21(1):56-8.