PMID- 17430227
OWN - NLM
STAT- MEDLINE
DCOM- 20070510
LR  - 20190917
IS  - 1389-5575 (Print)
IS  - 1389-5575 (Linking)
VI  - 7
IP  - 4
DP  - 2007 Apr
TI  - Involvement of dendritic cells in allograft rejection new implications of 
      dendritic cell-endothelial cell interactions.
PG  - 423-8
AB  - For almost half a century immunologists have tried to tear down the MHC barrier, 
      which separates two unrelated individuals during transplantation. Latest 
      experimental data suggest that a breakthrough in vitro is imminent. Dendritic 
      cells (DCs), which activate naive allo-reactive T-cells (TCs), play a central 
      role in the establishment of allo-antigen-specific immunity. Allograft solid 
      organ rejection is initiated at the foreign endothelial cell (EC) layer, which 
      forms an immunogenic barrier for migrating DCs. Thus, DC/EC interactions might 
      play a crucial role in antigen-specific allograft rejection. Organ rejection is 
      mediated by host allo-reactive TCs, which are activated by donor DCs (direct 
      activation) or host DCs (indirect activation). Direct allo-antigen presentation 
      by regulatory dendritic cells (DCreg) can play an instructive role towards 
      tolerance induction. Several groups established that, DCregs, if transplanted 
      beforehand, enter host thymus, spleen, or bone marrow where they might eventually 
      establish allo-antigen-specific tolerance. A fundamental aspect of DC function is 
      migration throughout the entire organism. After solid organ transplantation, host 
      DCs bind to ECs, invade allograft tissues, and finally transmigrate into lymphoid 
      vessels and secondary lymphoid organs, where they present allo-antigens to naive 
      host TCs. Recent data suggest that in vitro manipulated DCregs may mediate 
      allo-transplantation tolerance induction. However, the fundamental mechanisms on 
      how such DCregs cause host TCs in the periphery towards tolerance remain unclear. 
      One very promising experimental concept is the simultaneous manipulation of DC 
      direct and indirect TC activation/suppression, towards donor antigen-specific 
      allo-transplantation tolerance. The allo-antigen-specific long-term tolerance 
      induction mediated by DCreg pre-transplantation (with simultaneous short-term 
      immunosuppression) has become reproducible in the laboratory animal setting. 
      Despite the shortcomings of laboratory animal studies, strong promises are 
      deriving from these studies for clinical kidney, heart, and liver 
      transplantation.
FAU - Schlichting, C L
AU  - Schlichting CL
AD  - Department of Surgery, Division of Transplantation Surgery, School of Medicine, 
      University Hospital, University Rostock, Schillingallee 35, 18055 Rostock, 
      Germany. christoph.schlichting@drschlichting.de
FAU - Schareck, W D
AU  - Schareck WD
FAU - Kofler, S
AU  - Kofler S
FAU - Weis, M
AU  - Weis M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Mini Rev Med Chem
JT  - Mini reviews in medicinal chemistry
JID - 101094212
SB  - IM
MH  - Cell Movement
MH  - Dendritic Cells/cytology/*immunology
MH  - Endothelium/cytology/*immunology
MH  - *Graft Rejection
MH  - Humans
RF  - 93
EDAT- 2007/04/14 09:00
MHDA- 2007/05/11 09:00
CRDT- 2007/04/14 09:00
PHST- 2007/04/14 09:00 [pubmed]
PHST- 2007/05/11 09:00 [medline]
PHST- 2007/04/14 09:00 [entrez]
AID - 10.2174/138955707780363828 [doi]
PST - ppublish
SO  - Mini Rev Med Chem. 2007 Apr;7(4):423-8. doi: 10.2174/138955707780363828.