PMID- 17430488
OWN - NLM
STAT- MEDLINE
DCOM- 20070919
LR  - 20131121
IS  - 1397-3142 (Print)
IS  - 1397-3142 (Linking)
VI  - 11
IP  - 3
DP  - 2007 May
TI  - Oral graft vs. host disease in children--treatment with topical tacrolimus 
      ointment.
PG  - 306-11
AB  - Oral chronic graft vs. host disease (GVHD) frequently presents in patients with 
      sclerotic features of skin GVHD and is often associated with considerable 
      limitations of oral food intake and decreased quality of life. Systemic 
      tacrolimus is efficacious for prophylaxis and treatment of acute and chronic GVHD 
      and topical tacrolimus has shown activity in chronic GVHD skin lesions. We 
      therefore initiated a pilot study to investigate the safety and efficacy of 
      topical tacrolimus ointment in children with oral GVHD. Six patients suffering 
      from oral GVHD (five chronic and one acute) were included in the study. 
      Tacrolimus ointment 0.1% was applied twice daily using sterile gauze. The only 
      side-effects observed were a slight burning discomfort after the first 
      application in one patient and after food intake in another patient. Tacrolimus 
      was absorbed systemically in four of six patients. Of six patients, we observed a 
      complete response in two, a very good partial response (VGPR) in two, and a PR in 
      two patients, respectively. We conclude that topical application of tacrolimus 
      ointment holds promise as a safe and efficacious treatment for oral GVHD in 
      children. The Food and Drug Administration has recently issued a health advisory 
      about a potential cancer risk associated with topical tacrolimus treatment of the 
      skin; therefore, its benefits should be weighed against its potential risks and 
      diligent long-term follow-up should be carried out especially in children.
FAU - Albert, Michael H
AU  - Albert MH
AD  - Department of Pediatric Hematology/Oncology, Dr von Haunersches Kinderspital, 
      Ludwig Maximilians University, Munich, Germany. mialbert@gmail.com
FAU - Becker, B
AU  - Becker B
FAU - Schuster, F R
AU  - Schuster FR
FAU - Klein, B
AU  - Klein B
FAU - Binder, V
AU  - Binder V
FAU - Adam, K
AU  - Adam K
FAU - Nienhoff, C
AU  - Nienhoff C
FAU - Fuhrer, M
AU  - Fuhrer M
FAU - Borkhardt, A
AU  - Borkhardt A
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Pediatr Transplant
JT  - Pediatric transplantation
JID - 9802574
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Ointments)
RN  - WM0HAQ4WNM (Tacrolimus)
SB  - IM
MH  - Administration, Topical
MH  - Adolescent
MH  - Child
MH  - Female
MH  - Graft vs Host Disease/*drug therapy/etiology
MH  - Hematopoietic Stem Cell Transplantation/adverse effects
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Male
MH  - Mouth Diseases/*drug therapy/etiology
MH  - Ointments
MH  - Pilot Projects
MH  - Tacrolimus/*therapeutic use
MH  - Treatment Outcome
EDAT- 2007/04/14 09:00
MHDA- 2007/09/20 09:00
CRDT- 2007/04/14 09:00
PHST- 2007/04/14 09:00 [pubmed]
PHST- 2007/09/20 09:00 [medline]
PHST- 2007/04/14 09:00 [entrez]
AID - PTR666 [pii]
AID - 10.1111/j.1399-3046.2006.00666.x [doi]
PST - ppublish
SO  - Pediatr Transplant. 2007 May;11(3):306-11. doi: 10.1111/j.1399-3046.2006.00666.x.