PMID- 17432568
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20161018
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 25
IP  - 1
DP  - 2007 Jan
TI  - [Determination of amphetamines in human hair using dynamic liquid-phase 
      microextraction and gas chromatography/selected ion monitoring-mass spectrometry 
      after microwave derivatization].
PG  - 16-20
AB  - Human hair is an important specimen for drug abuse analysis owing to its easy 
      collection, long surveillance time window and good correlation between the 
      "degree of addiction" and actual drug concentration. A simple method for 
      determination of 4 amphetamines in human hair was developed. The hair was 
      digested under basic condition, and the drugs in it were extracted using 
      microvolume of chloroform. The organic layer was then transferred into another 
      tube to be derivatized with N-methyl-bis (trifluoroacetamide) (MBTFA) by 
      microwave heating. Finally the reacted solution was detected by gas 
      chromatography/selected ion monitoring-mass spectrometry (GC/SIM-MS) directly. 
      2-Methyl-phenyl ethylamine was used as an internal standard. Good linearities 
      were obtained for 4 amphetamines with correlation coefficients better than 0.996. 
      The limits of detection, based on a signal-to-noise ratio (S/N) of 3:1, were all 
      about 50 pg/mg for amphetamine (AM) , methamphetamine (MAM), 
      methylenedioxy-amphetamine (MDA), and methylenedioxy-methamphetamine (MDMA) in 
      hair. The reproducibility of the method was satisfactory, with the relative 
      standard deviations of 6.0% for AM, 13.9% for MAM, 10.2% for MDA and 9.2% for 
      MDMA. Some real hair from the drug abusers was analyzed with this method. The 
      minimal hair is less than 5 mg (about 20 cm). The method is highly sensitive, 
      easy to operate, time-saving and economic, which can be used for trace analysis 
      of amphetamines in human hair.
FAU - Zhu, Dan
AU  - Zhu D
AD  - Department of Forensic Science, Chinese People's Public Security University, 
      Beijing 100038, China. nadine401@163.com
FAU - Meng, Pinjia
AU  - Meng P
FAU - He, Hongyuan
AU  - He H
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Amphetamines)
SB  - IM
MH  - Amphetamines/*analysis
MH  - Chemical Fractionation/*methods
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Hair/*chemistry
MH  - Humans
MH  - *Microwaves
MH  - Reproducibility of Results
EDAT- 2007/04/17 09:00
MHDA- 2010/06/11 06:00
CRDT- 2007/04/17 09:00
PHST- 2007/04/17 09:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
PHST- 2007/04/17 09:00 [entrez]
PST - ppublish
SO  - Se Pu. 2007 Jan;25(1):16-20.