PMID- 17432674 OWN - NLM STAT- MEDLINE DCOM- 20080509 LR - 20161018 IS - 1003-5370 (Print) IS - 1003-5370 (Linking) VI - 27 IP - 3 DP - 2007 Mar TI - [Effect of Danzhi Xiaoyao Powder on neuro-immuno-endocrine system in patients with depression]. PG - 197-200 AB - OBJECTIVE: To observe the effect of Danzhi Xiaoyao Powder (DXP) on neuro-immuno-endocrine system in patients with depression. METHODS: A randomized double-blinded and controlled study was conducted in 63 cases of depression. They were assigned to the DXP group (32 cases, treated with DXP) and the control group (31 cases, treated with maprotiline). The curative effect was evaluated with Hamilton's depressive scale (HAMD) before and at the end of the 2nd, 4th and 6th week of the treatment. Serum levels of serotonin (5-HT), norepinephrine (NE), brain derived neurotrophic factor (BDNF), cortisol (CORT), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) were detected before and at the 6th week of the treatment. RESULTS: After 2 weeks of treatment, the total score of HAMD decreased remarkably in both groups (P < 0.01), and the total score, as well as the scores of the three factors, i. e. anxiety/somatization, cognitive impairment and feeling of despair, were lower in the DXP group than that in the control group respectively (P < 0.05 or P < 0.01). After 4 and 6 weeks of treatment the total score and score of the three factors all reduced significantly in both groups (P < 0.01), with insignificant difference between the groups. After 6 weeks of treatment, the serum levels of 5-HT and BDNF increased (P < 0.01), and the serum IL-6 level decreased in both groups (P < 0.05 or P < 0.01), the serum CORT level reduced in the DXP group (P < 0.01), while the serum NE level elevated in the control group (P < 0.01). CONCLUSION: DXP is effective in improving symptoms of depression by regulating the levels of 5-HT, BDNF, CORT and IL-6. FAU - Li, Yu-juan AU - Li YJ AD - Department of Integrative Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing. FAU - Luo, He-chun AU - Luo HC FAU - Qian, Rui-qin AU - Qian RQ LA - chi PT - English Abstract PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - China TA - Zhongguo Zhong Xi Yi Jie He Za Zhi JT - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine JID - 9211576 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Drugs, Chinese Herbal) RN - 0 (Interleukin-6) RN - 0 (xiaoyao) RN - 333DO1RDJY (Serotonin) RN - X4W3ENH1CV (Norepinephrine) SB - IM MH - Adolescent MH - Adult MH - Brain-Derived Neurotrophic Factor/*blood MH - Depressive Disorder/blood/*drug therapy/psychology MH - Double-Blind Method MH - Drugs, Chinese Herbal/*therapeutic use MH - Female MH - Humans MH - Interleukin-6/blood MH - Male MH - Middle Aged MH - Norepinephrine/blood MH - *Phytotherapy MH - Psychiatric Status Rating Scales MH - Serotonin/*blood EDAT- 2007/04/17 09:00 MHDA- 2008/05/10 09:00 CRDT- 2007/04/17 09:00 PHST- 2007/04/17 09:00 [pubmed] PHST- 2008/05/10 09:00 [medline] PHST- 2007/04/17 09:00 [entrez] PST - ppublish SO - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Mar;27(3):197-200.