PMID- 17432956
OWN - NLM
STAT- MEDLINE
DCOM- 20070626
LR  - 20141120
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 25
IP  - 6
DP  - 2007 Mar
TI  - Brain-derived neurotrophic factor modulates cell excitability in the mouse medial 
      nucleus of the trapezoid body.
PG  - 1647-52
AB  - Neurotrophins are a large class of trophic factors located throughout the central 
      nervous system. While the role of neurotrophins in neuronal survival and axon 
      guidance is well known, their secondary role in modulating synaptic transmission 
      and cell firing properties is largely unexplored. In this study we examined the 
      expression of neurotrophins in the mouse medial nucleus of the trapezoid body 
      (MNTB) and investigated the effect of exogenous brain-derived neurotrophic factor 
      (BDNF) application on the firing properties of MNTB principal cells. The 
      expression levels of nerve growth factor, BDNF, neurotrophin-3, neurotrophin-4/5 
      and major receptor tyrosine kinase B was found to be moderate to high at 
      postnatal day 12, indicating that the neurotrophins may have a role following 
      synaptogenesis. A 2-h exposure to exogenous BDNF (100 ng/mL) had a significant 
      effect on principal cell firing properties and voltage-gated potassium currents. 
      Importantly, preincubation in BDNF increased the incidence of multifiring and 
      rebounding cells, and significantly increased the number of action potentials 
      fired in response to a single depolarizing step. BDNF exposure also significantly 
      decreased underlying voltage-gated potassium currents, including both the low- 
      and high-voltage-activated components. Our data show that the neurotrophins, 
      specifically BDNF, may have a novel role in modulating cell excitability in the 
      auditory brainstem.
FAU - Youssoufian, M
AU  - Youssoufian M
AD  - Division of Neuroscience, John Curtin School of Medical Research, Australian 
      National University, Canberra, ACT, Australia. monique.youssoufian@anu.edu.au
FAU - Walmsley, B
AU  - Walmsley B
LA  - eng
PT  - Journal Article
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 660YQ98I10 (Potassium Chloride)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Action Potentials/*drug effects
MH  - Animals
MH  - Animals, Newborn
MH  - Brain Stem/*cytology
MH  - Brain-Derived Neurotrophic Factor/*metabolism/*pharmacology
MH  - Dose-Response Relationship, Radiation
MH  - Electric Stimulation
MH  - Gene Expression Regulation, Developmental/*physiology
MH  - In Vitro Techniques
MH  - Membrane Potentials/drug effects
MH  - Mice
MH  - Mice, Inbred CBA
MH  - Nerve Growth Factors/metabolism
MH  - Neurons/*drug effects
MH  - Patch-Clamp Techniques
MH  - Potassium Chloride/pharmacology
MH  - Receptor, trkB/metabolism
EDAT- 2007/04/17 09:00
MHDA- 2007/06/27 09:00
CRDT- 2007/04/17 09:00
PHST- 2007/04/17 09:00 [pubmed]
PHST- 2007/06/27 09:00 [medline]
PHST- 2007/04/17 09:00 [entrez]
AID - EJN5428 [pii]
AID - 10.1111/j.1460-9568.2007.05428.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2007 Mar;25(6):1647-52. doi: 10.1111/j.1460-9568.2007.05428.x.