PMID- 17433502
OWN - NLM
STAT- MEDLINE
DCOM- 20081013
LR  - 20181113
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Print)
IS  - 0197-4580 (Linking)
VI  - 29
IP  - 9
DP  - 2008 Sep
TI  - Effects of aging and caloric restriction on dentate gyrus synapses and glutamate 
      receptor subunits.
PG  - 1308-18
AB  - Caloric restriction (CR) attenuates aging-related degenerative processes 
      throughout the body. It is less clear, however, whether CR has a similar effect 
      in the brain, particularly in the hippocampus, an area important for learning and 
      memory processes that often are compromised in aging. In order to evaluate the 
      effect of CR on synapses across lifespan, we quantified synapses stereologically 
      in the middle molecular layer of the dentate gyrus (DG) of young, middle aged and 
      old Fischer 344 x Brown Norway rats fed ad libitum (AL) or a CR diet from 4 
      months of age. The results indicate that synapses are maintained across lifespan 
      in both AL and CR rats. In light of this stability, we addressed whether aging 
      and CR influence neurotransmitter receptor levels by measuring subunits of NMDA 
      (NR1, NR2A and NR2B) and AMPA (GluR1, GluR2) receptors in the DG of a second 
      cohort of AL and CR rats across lifespan. The results reveal that the NR1 and 
      GluR1 subunits decline with age in AL, but not CR rats. The absence of an 
      aging-related decline in these subunits in CR rats, however, does not arise from 
      increased levels in old CR rats. Instead, it is due to subunit decreases in young 
      CR rats to levels that are sustained in CR rats throughout lifespan, but that are 
      reached in AL rats only in old age.
FAU - Newton, Isabel G
AU  - Newton IG
AD  - Department of Neurobiology and Anatomy, Medical Center Boulevard, Wake Forest 
      University School of Medicine, Winston-Salem, NC 27157-1010, USA.
FAU - Forbes, M Elizabeth
AU  - Forbes ME
FAU - Linville, M Constance
AU  - Linville MC
FAU - Pang, Hui
AU  - Pang H
FAU - Tucker, Elizabeth W
AU  - Tucker EW
FAU - Riddle, David R
AU  - Riddle DR
FAU - Brunso-Bechtold, Judy K
AU  - Brunso-Bechtold JK
LA  - eng
GR  - R01 AG019886-05/AG/NIA NIH HHS/United States
GR  - R01 AG019886/AG/NIA NIH HHS/United States
GR  - P01 AG011370-040003/AG/NIA NIH HHS/United States
GR  - R01 AG019886-01/AG/NIA NIH HHS/United States
GR  - R01 AG019886-04/AG/NIA NIH HHS/United States
GR  - R01 AG019886-02/AG/NIA NIH HHS/United States
GR  - P01 AG011370-07S10003/AG/NIA NIH HHS/United States
GR  - P01 AG011370-050003/AG/NIA NIH HHS/United States
GR  - P01 AG011370-090003/AG/NIA NIH HHS/United States
GR  - AG019886/AG/NIA NIH HHS/United States
GR  - R01 AG019886-03/AG/NIA NIH HHS/United States
GR  - P01 AG011370/AG/NIA NIH HHS/United States
GR  - P01 AG011370-070003/AG/NIA NIH HHS/United States
GR  - P01 AG011370-060003/AG/NIA NIH HHS/United States
GR  - P01 AG011370-08A10003/AG/NIA NIH HHS/United States
GR  - P01 AG011370-07S20003/AG/NIA NIH HHS/United States
GR  - P01 AG011370-100003/AG/NIA NIH HHS/United States
GR  - AG11370/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070411
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Protein Subunits)
RN  - 0 (Receptors, Glutamate)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Aging/*metabolism/*pathology
MH  - Animals
MH  - Caloric Restriction/*methods
MH  - Dentate Gyrus/*metabolism/*pathology
MH  - Humans
MH  - Male
MH  - Models, Animal
MH  - Protein Subunits/metabolism
MH  - Rats
MH  - Rats, Inbred F344
MH  - Receptors, Glutamate/*metabolism
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
MH  - Synapses/*metabolism/*pathology
PMC - PMC2805132
MID - NIHMS62199
EDAT- 2007/04/17 09:00
MHDA- 2008/10/14 09:00
PMCR- 2010/01/12
CRDT- 2007/04/17 09:00
PHST- 2006/03/24 00:00 [received]
PHST- 2007/02/19 00:00 [revised]
PHST- 2007/03/06 00:00 [accepted]
PHST- 2007/04/17 09:00 [pubmed]
PHST- 2008/10/14 09:00 [medline]
PHST- 2007/04/17 09:00 [entrez]
PHST- 2010/01/12 00:00 [pmc-release]
AID - S0197-4580(07)00118-2 [pii]
AID - 10.1016/j.neurobiolaging.2007.03.009 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2008 Sep;29(9):1308-18. doi: 
      10.1016/j.neurobiolaging.2007.03.009. Epub 2007 Apr 11.