PMID- 17434282
OWN - NLM
STAT- MEDLINE
DCOM- 20070815
LR  - 20220408
IS  - 0736-5748 (Print)
IS  - 0736-5748 (Linking)
VI  - 25
IP  - 4
DP  - 2007 Jun
TI  - The influence of maternal treadmill running during pregnancy on short-term memory 
      and hippocampal cell survival in rat pups.
PG  - 243-9
AB  - Maternal exercise during pregnancy has been suggested to exert the beneficial 
      effects on the brain functions of offspring. In the present study, we attempted 
      to determine the effects of maternal treadmill running during pregnancy on 
      short-term memory ability, hippocampal cell survival, and the expression of 
      brain-derived neurotrophic factor (BDNF) mRNA in rat pups. After confirming 
      pregnancy, the pregnant rats were divided into two groups: the control group and 
      the running group (n = 6 in each group). Beginning on the 15th day of pregnancy, 
      the pregnant rats in the running group were forced to run on a treadmill for 30 
      min at a mild-intensity, once a day until delivery. After all the pregnant rats 
      had given birth, there were rat pups available for use in this study in each 
      group (n = 15 in each group). The latency of the step-down avoidance task was 
      used in order to evaluate the short-term memory ability of the rat pups on the 28 
      days after birth. Immunohistochemistry for 5-bromo-2'-deoxyuridine (BrdU) and 
      reverse transcription-polymerase chain reaction (RT-PCR) for BDNF mRNA were 
      performed to determine hippocampal neurogenesis and hippocampal BDNF mRNA 
      expression of the rat pups on the 29 days after birth, respectively. Our results 
      revealed that maternal running during pregnancy resulted in significant increase 
      in the expression of BDNF mRNA, enhanced hippocampal cell survival, and improved 
      the short-term memory capability of rat pups, as compared to those measured in 
      the control group. The findings of our study provide evidence that maternal 
      running during gestational period may enhance the brain functions of offspring.
FAU - Kim, Hong
AU  - Kim H
AD  - Department of Physiology, College of Medicine, Kyung Hee University, #1 
      Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea.
FAU - Lee, Sang-Hak
AU  - Lee SH
FAU - Kim, Sung-Soo
AU  - Kim SS
FAU - Yoo, Jae-Hyun
AU  - Yoo JH
FAU - Kim, Chang-Ju
AU  - Kim CJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070318
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Behavior, Animal
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Bromodeoxyuridine/metabolism
MH  - Cell Survival/physiology
MH  - Exercise Test/methods
MH  - Female
MH  - Gene Expression Regulation, Developmental
MH  - Hippocampus/*cytology
MH  - Male
MH  - Memory, Short-Term/*physiology
MH  - Neurons/*physiology
MH  - Pregnancy
MH  - Pregnancy, Animal/*physiology
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reaction Time/physiology
MH  - Reverse Transcriptase Polymerase Chain Reaction/methods
MH  - Running/*physiology
EDAT- 2007/04/17 09:00
MHDA- 2007/08/19 09:00
CRDT- 2007/04/17 09:00
PHST- 2006/02/17 00:00 [received]
PHST- 2007/03/04 00:00 [revised]
PHST- 2007/03/06 00:00 [accepted]
PHST- 2007/04/17 09:00 [pubmed]
PHST- 2007/08/19 09:00 [medline]
PHST- 2007/04/17 09:00 [entrez]
AID - S0736-5748(07)00039-1 [pii]
AID - 10.1016/j.ijdevneu.2007.03.003 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2007 Jun;25(4):243-9. doi: 10.1016/j.ijdevneu.2007.03.003. 
      Epub 2007 Mar 18.