PMID- 17434455
OWN - NLM
STAT- MEDLINE
DCOM- 20070801
LR  - 20161122
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 61
IP  - 10
DP  - 2007 May 15
TI  - Medial frontal hyperactivity in reality distortion.
PG  - 1171-8
AB  - BACKGROUND: Schizophrenia/schizoaffective disorder involves reality distortion 
      (RD), which impairs the ability to process socioemotional information. Because 
      this psychological capacity maps to the medial prefrontal cortex (MPFC) and 
      schizophrenia involves abnormal MPFC function, we tested the hypothesis that 
      treated schizophrenic/schizoaffective patients with persistent RD (RD+) would 
      exhibit greater MPFC dysfunction than patients without significant RD (RD-). The 
      amygdala interacts with MPFC, also carries out socioemotional processing, and has 
      been implicated in schizophrenia; thus, we also tested the hypothesis that 
      patients would exhibit aberrant amygdala activity. METHODS: Eleven RD+ patients, 
      12 RD- patients, and 15 healthy control subjects (HC) viewed emotionally salient 
      pictures with neutral, aversive, and positive content during the acquisition of 
      blood oxygenation level-dependent (BOLD) sensitive functional magnetic resonance 
      imaging. RESULTS: All groups had similar behavioral responses to the pictures. 
      The RD+ subjects had greater BOLD responses (compared with the RD- and HC groups) 
      to the aversive pictures in the anterior MPFC. Both patient groups showed reduced 
      activation in MPFC and the left amygdala (compared with HC) for neutral pictures 
      (compared with blank condition), although this effect could be explained by 
      medication. CONCLUSIONS: Reality distortion is associated with hyperactivity of 
      the MPFC in schizophrenic/schizoaffective patients whose symptoms persist in 
      spite of antipsychotic treatment.
FAU - Taylor, Stephan F
AU  - Taylor SF
AD  - Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, 
      Michigan 48109-5765, USA. sftaylor@umich.edu
FAU - Welsh, Robert C
AU  - Welsh RC
FAU - Chen, Ashley C
AU  - Chen AC
FAU - Velander, Alan J
AU  - Velander AJ
FAU - Liberzon, Israel
AU  - Liberzon I
LA  - eng
GR  - R01 MH064148/MH/NIMH NIH HHS/United States
GR  - R01 MH064148-04/MH/NIMH NIH HHS/United States
GR  - R01 MH01258/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070416
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adult
MH  - Amygdala/drug effects/physiopathology
MH  - Antipsychotic Agents/therapeutic use
MH  - Brain Mapping
MH  - Dominance, Cerebral/physiology
MH  - Emotions/drug effects/physiology
MH  - Female
MH  - Frontal Lobe/drug effects/*physiopathology
MH  - Humans
MH  - *Image Enhancement
MH  - *Image Processing, Computer-Assisted
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Oxygen Consumption/drug effects/physiology
MH  - Pattern Recognition, Visual/drug effects/physiology
MH  - Perceptual Distortion/drug effects/*physiology
MH  - *Reality Testing
MH  - Schizophrenia/diagnosis/drug therapy/*physiopathology
MH  - *Schizophrenic Psychology
MH  - Social Perception
EDAT- 2007/04/17 09:00
MHDA- 2007/08/02 09:00
CRDT- 2007/04/17 09:00
PHST- 2006/03/23 00:00 [received]
PHST- 2006/11/28 00:00 [revised]
PHST- 2006/11/29 00:00 [accepted]
PHST- 2007/04/17 09:00 [pubmed]
PHST- 2007/08/02 09:00 [medline]
PHST- 2007/04/17 09:00 [entrez]
AID - S0006-3223(06)01537-X [pii]
AID - 10.1016/j.biopsych.2006.11.029 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2007 May 15;61(10):1171-8. doi: 10.1016/j.biopsych.2006.11.029. 
      Epub 2007 Apr 16.