PMID- 17434552
OWN - NLM
STAT- MEDLINE
DCOM- 20070801
LR  - 20191210
IS  - 0042-6822 (Print)
IS  - 0042-6822 (Linking)
VI  - 364
IP  - 2
DP  - 2007 Aug 1
TI  - Recombinant simian varicella viruses induce immune responses to simian 
      immunodeficiency virus (SIV) antigens in immunized vervet monkeys.
PG  - 291-300
AB  - The varicella-zoster virus (VZV) Oka vaccine offers potential as a recombinant 
      vaccine against other pathogens. In this study, recombinant simian varicella 
      viruses (rSVV) expressing simian immunodeficiency virus (SIV) envelope (env, 
      gp130) and gag antigens were constructed. Expression of the SIV env and gag 
      transcripts and antigens in rSVV-infected Vero cells was confirmed. The 
      rSVV-SIVenv and rSVV-SIVgag viruses replicated as efficiently as wild-type SVV in 
      cell culture. The immunogenicity of rSVV-SIVenv and rSVV-SIVgag was investigated 
      in immunized vervet monkeys. Humoral immune responses to the SIV gp130 and gag 
      antigens were detected as early as 4 weeks after the initial immunization with 
      higher antibody titers following a booster immunization. Cellular immune 
      responses against the SIV gp130 antigen were detected by ELISPOT assay. The rSVV 
      established latent infection in neural ganglia. A subsequent study will evaluate 
      the ability of rSVV vaccines expressing SIV antigens to protect nonhuman primates 
      against simian AIDS.
FAU - Ou, Yang
AU  - Ou Y
AD  - Department of Microbiology and Immunology, Slot 511, University of Arkansas for 
      Medical Sciences, Little Rock, AR 72205, USA.
FAU - Traina-Dorge, Vicki
AU  - Traina-Dorge V
FAU - Davis, Kara A
AU  - Davis KA
FAU - Gray, Wayne L
AU  - Gray WL
LA  - eng
GR  - AI052373/AI/NIAID NIH HHS/United States
GR  - R01 AI052373-03/AI/NIAID NIH HHS/United States
GR  - R01 AI052373-05/AI/NIAID NIH HHS/United States
GR  - R01 AI052373/AI/NIAID NIH HHS/United States
GR  - R01 AI052373-04/AI/NIAID NIH HHS/United States
GR  - R01 AI052373-02/AI/NIAID NIH HHS/United States
GR  - R01 AI052373-01A1/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070416
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (Antibodies, Viral)
RN  - 0 (Chickenpox Vaccine)
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Viral)
RN  - 0 (Gene Products, env)
RN  - 0 (Gene Products, gag)
RN  - 0 (RNA, Viral)
RN  - 0 (SAIDS Vaccines)
RN  - 0 (Vaccines, Synthetic)
RN  - 0 (simian immunodeficiency virus gp130)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/biosynthesis
MH  - Base Sequence
MH  - Cell Line
MH  - Chickenpox Vaccine/administration & dosage/genetics
MH  - Chlorocebus aethiops
MH  - DNA Primers/genetics
MH  - DNA, Viral/genetics/isolation & purification
MH  - Ganglia/virology
MH  - Gene Products, env/genetics/immunology
MH  - Gene Products, gag/genetics/immunology
MH  - Herpesvirus 3, Human/genetics/*immunology/physiology
MH  - Immunity, Cellular
MH  - Immunization
MH  - Immunization, Secondary
MH  - Models, Animal
MH  - RNA, Viral/genetics/isolation & purification
MH  - Recombination, Genetic
MH  - SAIDS Vaccines/administration & dosage/genetics
MH  - Simian Immunodeficiency Virus/genetics/*immunology/physiology
MH  - Vaccines, Synthetic/administration & dosage/genetics
MH  - Vero Cells
MH  - Virus Replication
PMC - PMC1986657
MID - NIHMS25799
EDAT- 2007/04/17 09:00
MHDA- 2007/08/02 09:00
PMCR- 2008/08/01
CRDT- 2007/04/17 09:00
PHST- 2006/10/09 00:00 [received]
PHST- 2007/01/04 00:00 [revised]
PHST- 2007/03/09 00:00 [accepted]
PHST- 2007/04/17 09:00 [pubmed]
PHST- 2007/08/02 09:00 [medline]
PHST- 2007/04/17 09:00 [entrez]
PHST- 2008/08/01 00:00 [pmc-release]
AID - S0042-6822(07)00171-7 [pii]
AID - 10.1016/j.virol.2007.03.025 [doi]
PST - ppublish
SO  - Virology. 2007 Aug 1;364(2):291-300. doi: 10.1016/j.virol.2007.03.025. Epub 2007 
      Apr 16.