PMID- 17434720
OWN - NLM
STAT- MEDLINE
DCOM- 20071113
LR  - 20161124
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Linking)
VI  - 17
IP  - 9
DP  - 2007 Nov
TI  - An analysis of peroxisome proliferator-activated receptor gamma (PPAR-gamma 2) 
      Pro12Ala polymorphism distribution and prevalence of type 2 diabetes mellitus 
      (T2DM) in world populations in relation to dietary habits.
PG  - 632-41
AB  - BACKGROUND AND AIM: The human peroxisome proliferator-activated receptor gamma 
      (PPAR-gamma) is involved in lipid storage, glucose homeostasis and adipocyte 
      differentiation. The Ala allele of the Pro12Ala polymorphism has been associated 
      with a protective effect against T2DM. Ala allele frequencies are known for many 
      populations, but data are absent for other interesting human groups. METHODS AND 
      RESULTS: We examined samples from Ethiopia, Benin, Ecuador and Italy. In 
      addition, we performed an analysis of the Pro12Ala polymorphism distribution in 
      world populations, also in relation to T2DM prevalence and the diet lipid 
      content. In the European populations, the Ala allele frequencies are distributed 
      according to a latitudinal trend, with the highest in the northern and central 
      European populations and the lowest in the Mediterranean populations. Considering 
      the world populations, a significant inverse relationship between Ala frequency 
      and T2DM prevalence was observed mainly in populations where energy from lipids 
      exceeded 30% of the total energy intake. CONCLUSION: Northern Europe's cold 
      climate has been hypothesised to have played a role in contributing to the 
      present pattern. Moreover our analysis appears to confirm, at a population level, 
      the protective effect of Ala allele against T2DM, already observed in 
      case-control studies, but only in populations with a diet rich in lipids.
FAU - Scacchi, R
AU  - Scacchi R
AD  - CNR Institute of Molecular Biology and Pathology, Rome, Italy. 
      renato.scacchi@uniroma1.it
FAU - Pinto, A
AU  - Pinto A
FAU - Rickards, O
AU  - Rickards O
FAU - Pacella, A
AU  - Pacella A
FAU - De Stefano, G F
AU  - De Stefano GF
FAU - Cannella, C
AU  - Cannella C
FAU - Corbo, R M
AU  - Corbo RM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070416
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
RN  - 0 (Dietary Fats)
RN  - 0 (PPAR gamma)
RN  - 9DLQ4CIU6V (Proline)
RN  - OF5P57N2ZX (Alanine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alanine
MH  - Benin/epidemiology
MH  - Climate
MH  - Diabetes Mellitus, Type 2/*epidemiology/*genetics
MH  - Dietary Fats/*administration & dosage/adverse effects
MH  - Ecuador/epidemiology
MH  - *Environment
MH  - Ethiopia/epidemiology
MH  - Feeding Behavior
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Italy/epidemiology
MH  - Male
MH  - Middle Aged
MH  - PPAR gamma/*genetics
MH  - *Polymorphism, Genetic
MH  - Prevalence
MH  - Proline
EDAT- 2007/04/17 09:00
MHDA- 2007/11/14 09:00
CRDT- 2007/04/17 09:00
PHST- 2006/09/12 00:00 [received]
PHST- 2006/11/23 00:00 [revised]
PHST- 2006/12/11 00:00 [accepted]
PHST- 2007/04/17 09:00 [pubmed]
PHST- 2007/11/14 09:00 [medline]
PHST- 2007/04/17 09:00 [entrez]
AID - S0939-4753(06)00267-5 [pii]
AID - 10.1016/j.numecd.2006.12.007 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2007 Nov;17(9):632-41. doi: 
      10.1016/j.numecd.2006.12.007. Epub 2007 Apr 16.