PMID- 17436203
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20070828
IS  - 0172-4622 (Print)
IS  - 0172-4622 (Linking)
VI  - 28
IP  - 9
DP  - 2007 Sep
TI  - Modulation of dendritic cells by endurance training.
PG  - 798-803
AB  - A periodized endurance training is able to adapt physical and psychological needs 
      and increase exercise performance. Dendritic cells (DCs) play a key role in 
      regulation of the immune response. In the present study, we trained 
      Sprague-Dawley (SD) rats for five weeks using a progressive endurance protocol 
      with the aim of measuring the effect on myeloid DC differentiation and 
      maturation. Rats were divided into a non-exercise group (NEG) and an exercise 
      group (EG). Bone marrow cells were isolated from these rats after training and 
      cultured in the presence of granulocyte/monocyte-colony stimulatory factor 
      (GM-CSF) and interleukin (IL)-4, and the resultant immature DCs were triggered 
      with lipopolysaccharide to mature. DCs were collected and the main 
      characteristics of DCs were assessed. The recovery rate and the expression of 
      major histocompatibility complex (MHC) class II molecules for DC collected from 
      EG was markedly greater than NEG. The function of DCs from EG to trigger a mixed 
      leukocyte reaction and IL-12 production was higher than NEG. There was no liver 
      and renal toxicity observed in all rats. Changes in food/water consumption and 
      body weight increase between the groups were normal for the conditions. This 
      study demonstrated that periodized endurance training is able to modulate DC 
      development and shift them towards a more mature state.
FAU - Chiang, L-M
AU  - Chiang LM
AD  - Graduate Institute of Sport Coaching Science, Chinese Culture University, Taipei, 
      Taiwan - Republic of China.
FAU - Chen, Y-J
AU  - Chen YJ
FAU - Chiang, J
AU  - Chiang J
FAU - Lai, L-Y
AU  - Lai LY
FAU - Chen, Y-Y
AU  - Chen YY
FAU - Liao, H-F
AU  - Liao HF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070413
PL  - Germany
TA  - Int J Sports Med
JT  - International journal of sports medicine
JID - 8008349
RN  - 187348-17-0 (Interleukin-12)
RN  - 207137-56-2 (Interleukin-4)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Animals
MH  - Antigen-Presenting Cells
MH  - Body Weight
MH  - Bone Marrow/*physiology
MH  - Dendritic Cells/*physiology
MH  - Genes, MHC Class II
MH  - Granulocyte-Macrophage Colony-Stimulating Factor
MH  - Interleukin-12
MH  - Interleukin-4
MH  - Kidney/drug effects
MH  - Liver/drug effects
MH  - Lymphocyte Culture Test, Mixed
MH  - Physical Endurance/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
EDAT- 2007/04/17 09:00
MHDA- 2007/12/07 09:00
CRDT- 2007/04/17 09:00
PHST- 2007/04/17 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2007/04/17 09:00 [entrez]
AID - 10.1055/s-2007-964914 [doi]
PST - ppublish
SO  - Int J Sports Med. 2007 Sep;28(9):798-803. doi: 10.1055/s-2007-964914. Epub 2007 
      Apr 13.