PMID- 17439824
OWN - NLM
STAT- MEDLINE
DCOM- 20070730
LR  - 20080507
IS  - 0161-5890 (Print)
IS  - 0161-5890 (Linking)
VI  - 44
IP  - 14
DP  - 2007 Jul
TI  - Staphylococcal enterotoxin B increases TIM4 expression in human dendritic cells 
      that drives naive CD4 T cells to differentiate into Th2 cells.
PG  - 3580-7
AB  - Aberrant T helper (Th)2 polarization plays a critical role in the pathogenesis of 
      allergic disorders; the etiology remains unclear. Dendritic cells (DCs) express T 
      cell immunoglobulin mucin domain (TIM)4 that ligates TIM1 on CD4 T cells to drive 
      them to become Th2 cells, but the pathogenic source of TIM4 is unknown. Here we 
      report that a significant increase in TIM4 expression in human DCs was observed 
      in response to Staphylococcal enterotoxin B (SEB) stimulation via Toll-like 
      receptor (TLR)2 and nucleotide-binding oligomerization domain (NOD)1 pathway. 
      Coculture SEB-conditioned DCs with naive CD4 T cells induced Th2 responses that 
      could be abolished using TLR2 or NOD1 or TIM4 or TIM1 with counterpart antibodies 
      or RNA interference. The results demonstrate that Staphylococcus aureus derived 
      SEB promotes the TIM4 production in human DCs. The interaction between TIM4 and 
      TIM1 drives naive CD4 T cells to develop to Th2 cells.
FAU - Liu, Tao
AU  - Liu T
AD  - Allergy Research Unit, The First Hospital, Shanxi Medical University, Taiyuan, 
      Shanxi, China.
FAU - He, Shao-Heng
AU  - He SH
FAU - Zheng, Peng-Yuan
AU  - Zheng PY
FAU - Zhang, Tao-Yuan
AU  - Zhang TY
FAU - Wang, Bin-Quan
AU  - Wang BQ
FAU - Yang, Ping-Chang
AU  - Yang PC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070417
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
RN  - 0 (Culture Media, Conditioned)
RN  - 0 (Enterotoxins)
RN  - 0 (Membrane Proteins)
RN  - 0 (NOD1 protein, human)
RN  - 0 (Nod1 Signaling Adaptor Protein)
RN  - 0 (TIMD4 protein, human)
RN  - 0 (Toll-Like Receptor 2)
RN  - 187348-17-0 (Interleukin-12)
RN  - 39424-53-8 (enterotoxin B, staphylococcal)
SB  - IM
MH  - Cell Differentiation/*drug effects
MH  - Cell Polarity/drug effects
MH  - Cells, Cultured
MH  - Culture Media, Conditioned
MH  - Dendritic Cells/*drug effects/*metabolism
MH  - Enterotoxins/*pharmacology
MH  - Humans
MH  - Interleukin-12/metabolism
MH  - Membrane Proteins/*metabolism
MH  - Nod1 Signaling Adaptor Protein/metabolism
MH  - Protein Binding/drug effects
MH  - Th2 Cells/*cytology/*immunology
MH  - Toll-Like Receptor 2/metabolism
EDAT- 2007/04/19 09:00
MHDA- 2007/07/31 09:00
CRDT- 2007/04/19 09:00
PHST- 2007/01/11 00:00 [received]
PHST- 2007/02/18 00:00 [revised]
PHST- 2007/03/09 00:00 [accepted]
PHST- 2007/04/19 09:00 [pubmed]
PHST- 2007/07/31 09:00 [medline]
PHST- 2007/04/19 09:00 [entrez]
AID - S0161-5890(07)00118-6 [pii]
AID - 10.1016/j.molimm.2007.03.004 [doi]
PST - ppublish
SO  - Mol Immunol. 2007 Jul;44(14):3580-7. doi: 10.1016/j.molimm.2007.03.004. Epub 2007 
      Apr 17.