PMID- 17439912
OWN - NLM
STAT- MEDLINE
DCOM- 20070613
LR  - 20111117
IS  - 1352-4585 (Print)
IS  - 1352-4585 (Linking)
VI  - 13
IP  - 3
DP  - 2007 Apr
TI  - Correlations between Epstein-Barr virus antibody levels and risk factors for 
      multiple sclerosis in healthy individuals.
PG  - 420-3
AB  - BACKGROUND: Female gender, human leukocyte antigen (HLA) DR2, tobacco smoking and 
      Epstein-Barr virus (EBV) are established risk factors for multiple sclerosis 
      (MS). Their possible interaction however, has been sparsely studied. OBJECTIVES: 
      To investigate possible associations between EBV antibody levels and a range of 
      other recognized MS risk factors. DESIGN, SETTING AND STUDY POPULATION: 
      Cross-sectional study undertaken in Denmark based on 517 healthy individuals 
      selected from the Danish population. METHODS: We measured change in mean log 
      (anti-Epstein-Barr viral capsid antigen (VCA) immune globulin G) using linear 
      regression. RESULTS: Anti-Epstein-Barr VCA immune globulin G levels were 
      positively correlated with female gender and HLA DR2. Furthermore, current 
      smoking and cumulative tobacco consumption were positively associated with EBV 
      antibody levels. CONCLUSION: The association between Epstein-Barr VCA antibody 
      levels and non-viral MS risk factors support the view that EBV is critically 
      involved in the etiology of MS. These non-viral MS risk factors may be linked 
      with MS risk through EBV-specific immune responses.
FAU - Nielsen, T R
AU  - Nielsen TR
AD  - Department of Epidemiology Research, Statens Serum Institut, 2300 Copenhagen, 
      Denmark. trn@ssi.dk
FAU - Pedersen, M
AU  - Pedersen M
FAU - Rostgaard, K
AU  - Rostgaard K
FAU - Frisch, M
AU  - Frisch M
FAU - Hjalgrim, H
AU  - Hjalgrim H
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20070129
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
RN  - 0 (Antibodies, Viral)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Antibodies, Viral/*blood
MH  - Denmark
MH  - Female
MH  - HLA-DR Antigens/analysis
MH  - HLA-DRB1 Chains
MH  - Herpesvirus 4, Human/*immunology/*isolation & purification
MH  - Histocompatibility Testing
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Male
MH  - Multiple Sclerosis/*epidemiology/virology
MH  - Reference Values
MH  - Risk Factors
MH  - Sex Characteristics
EDAT- 2007/04/19 09:00
MHDA- 2007/06/15 09:00
CRDT- 2007/04/19 09:00
PHST- 2007/04/19 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2007/04/19 09:00 [entrez]
AID - 1352458506071470 [pii]
AID - 10.1177/1352458506071470 [doi]
PST - ppublish
SO  - Mult Scler. 2007 Apr;13(3):420-3. doi: 10.1177/1352458506071470. Epub 2007 Jan 
      29.