PMID- 17440683
OWN - NLM
STAT- MEDLINE
DCOM- 20070917
LR  - 20071203
IS  - 0167-7659 (Print)
IS  - 0167-7659 (Linking)
VI  - 26
IP  - 2
DP  - 2007 Jun
TI  - Hypoxia and radiotherapy: opportunities for improved outcomes in cancer 
      treatment.
PG  - 241-8
AB  - A large body of clinical evidence exists to suggest that tumor hypoxia negatively 
      impacts radiotherapy. As a result, there has been longstanding active research 
      into novel methods of improving tumor oxygenation, targeting hypoxic tumor cells, 
      and otherwise modulating the effect hypoxia has on how tumors respond to 
      radiation. Over time, as more has been learned about the many ways hypoxia 
      affects tumors, our understanding of the mechanisms connecting hypoxia to 
      radiosensitivity has become increasingly broad and complicated. This has opened 
      up new potential avenues for interrupting hypoxia's negative effects on tumor 
      radiosensitivity. Here, we will review what is currently known about the spectrum 
      of influence hypoxia has over the way tumors respond to radiation. Particular 
      focus will be placed on recent discoveries suggesting that hypoxia-inducible 
      factor-1 (HIF-1), a transcription factor that upregulates its target genes under 
      hypoxic conditions, plays a major role in determining tumor radiosensitivity. 
      HIF-1 and/or its target genes may represent therapeutic targets which could be 
      manipulated to influence hypoxia's impact on tumor radiosensitivity.
FAU - Moeller, Benjamin J
AU  - Moeller BJ
AD  - Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 
      USA,.
FAU - Richardson, Rachel A
AU  - Richardson RA
FAU - Dewhirst, Mark W
AU  - Dewhirst MW
LA  - eng
GR  - CA40355/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Cancer Metastasis Rev
JT  - Cancer metastasis reviews
JID - 8605731
SB  - IM
MH  - Cell Hypoxia/*radiation effects
MH  - Humans
MH  - Neoplasms/*physiopathology/*radiotherapy
MH  - Oxygen Consumption/radiation effects
MH  - Radiation Tolerance
MH  - Treatment Outcome
RF  - 56
EDAT- 2007/04/19 09:00
MHDA- 2007/09/18 09:00
CRDT- 2007/04/19 09:00
PHST- 2007/04/19 09:00 [pubmed]
PHST- 2007/09/18 09:00 [medline]
PHST- 2007/04/19 09:00 [entrez]
AID - 10.1007/s10555-007-9056-0 [doi]
PST - ppublish
SO  - Cancer Metastasis Rev. 2007 Jun;26(2):241-8. doi: 10.1007/s10555-007-9056-0.