PMID- 17440998
OWN - NLM
STAT- MEDLINE
DCOM- 20070926
LR  - 20071026
IS  - 1613-4125 (Print)
IS  - 1613-4125 (Linking)
VI  - 51
IP  - 5
DP  - 2007 May
TI  - Factor VII polymorphisms influence the plasma response to diets with different 
      fat content, in a healthy Caucasian population.
PG  - 618-24
AB  - To determine the influence of the factor VII gene polymorphisms, R353Q and 5'F7, 
      on factor VII Ag plasma levels after the consumption of diets with different fat 
      contents. METHODS: 59 healthy individuals (42 RR, 16 RQ, 1 QQ at the R353Q and 46 
      A1A1, 13 A1A2 at the 5'F7) consumed 3 diets during 4-weeks each: a Saturated diet 
      (SAT) enriched in saturated fatty acid (SFA) (38% fat, 20% SFA), followed by a 
      carbohydrate (CHO)-rich diet (30% fat, 55% CHO) or a Mediterranean diet (MEDIT) 
      enriched in monounsaturated fatty acid (MUFA) (38% fat, 22% MUFA) following a 
      randomized crossover design. Plasma lipids and FVII Ag plasma levels were 
      determined at the end of each dietary period. RESULTS: After a SAT diet, RR 
      homozygotes had greater concentrations of FVII Ag compared with MEDIT and CHO 
      diets than did carriers of the minority Q allele (82.76 +/- 1.3 vs. 75.02 +/- 
      2.4, p = 0.001). The 5'F7 polymorphism behaved in a similar fashion (A1A1 81.98 
      +/- 1.4 vs. A1A2 75.37 +/- 2.4, p = 0.026). CONCLUSIONS: Our data show that 
      carriers of the RR and/or A1A1 genotype present higher FVII Ag levels after the 
      consumption of a SAT diet compared with the MEDIT and CHO rich diets.
FAU - Fernandez de la Puebla, Rafael Angel
AU  - Fernandez de la Puebla RA
AD  - Reina Sofia University Hospital, Lipids and Atherosclerosis Research Unit, 
      University of Cordoba, Ciber Fisiopatologia Obesidad y Nutricion, Instituto Salud 
      Carlos III, Cordoba, Spain.
FAU - Perez-Martinez, Pablo
AU  - Perez-Martinez P
FAU - Carmona, Jose
AU  - Carmona J
FAU - Lopez-Miranda Carmen Marin, Jose
AU  - Lopez-Miranda Carmen Marin J
FAU - Paniagua, Juan Antonio
AU  - Paniagua JA
FAU - Fuentes, Francisco
AU  - Fuentes F
FAU - Perez-Jimenez, Francisco
AU  - Perez-Jimenez F
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Mol Nutr Food Res
JT  - Molecular nutrition & food research
JID - 101231818
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acids)
RN  - 9001-25-6 (Factor VII)
SB  - IM
MH  - Adult
MH  - Cross-Over Studies
MH  - Diet, Mediterranean
MH  - Dietary Carbohydrates/administration & dosage
MH  - Dietary Fats/*administration & dosage
MH  - Factor VII/*analysis/*genetics
MH  - Fatty Acids/administration & dosage
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - *Polymorphism, Genetic
EDAT- 2007/04/19 09:00
MHDA- 2007/09/27 09:00
CRDT- 2007/04/19 09:00
PHST- 2007/04/19 09:00 [pubmed]
PHST- 2007/09/27 09:00 [medline]
PHST- 2007/04/19 09:00 [entrez]
AID - 10.1002/mnfr.200600298 [doi]
PST - ppublish
SO  - Mol Nutr Food Res. 2007 May;51(5):618-24. doi: 10.1002/mnfr.200600298.