PMID- 17441314
OWN - NLM
STAT- MEDLINE
DCOM- 20090424
LR  - 20161020
IS  - 1001-9294 (Print)
IS  - 1001-9294 (Linking)
VI  - 22
IP  - 1
DP  - 2007 Mar
TI  - Plasma resistin levels and single-nucleotide polymorphisms in resistin gene 5' 
      flanking region in patients with stroke.
PG  - 27-32
AB  - OBJECTIVE: To analyze the role of resistin in insulin resistance (IR) through 
      investigating the variation of plasma resistin levels and single-nucleotide 
      polymorphisms (SNPs) in resistin gene 5' flanking region in stroke patients. 
      METHODS: In 103 atherothrombotic cerebral infarction (ACI) patients, 85 lacunar 
      infarction (LI) patients, 70 intracerebral hemorrhage (ICH) patients, and 86 
      healthy controls, plasma resistin and insulin levels were measured by ELISA, SNPs 
      in resistin gene 5' flanking region were detected by PCR and direct DNA 
      sequencing. The subjects' body height and weight, the body mass index, 
      quantitative insulin sensitivity check index (QUICKI), blood pressure, and the 
      concentration of fasting plasma glucose, triglyceride, total cholesterol, 
      creatinine, low-density lipoprotein, and high-density lipoprotein were also 
      determined. RESULTS: QUICKI was significantly lower in the ACI and ICH patients 
      (0.316 +/- 0.037 and 0.309 +/- 0.032, respectively) than that in the controls 
      (0.342 +/- 0.043, P < 0.001), while plasma resistin level was significantly 
      higher in the ACI and ICH patients (6.36 +/- 3.79 and 7.15 +/- 4.27 ng/mL, 
      respectively) than that in the controls (5.28 +/- 2.56 ng/mL, P < 0.05), but such 
      difference was not observed in the LI patients compared with controls. There was 
      a statistically negative correlation between plasma resistin level with QUICKI (r 
      = -0.228, P < 0.001). The distributions of allele and genotype frequencies of 
      resistin gene - 420C > G and - 537A > C SNPs were not significantly different 
      among the different groups, and those SNPs were not correlated with other 
      clinical and biochemical parameters. CONCLUSIONS: Plasma resistin is associated 
      with stroke by participating in the development of IR. The SNPs in resistin gene 
      5' flanking region has no impact on the plasma resistin level.
FAU - Lin, Xing-Jian
AU  - Lin XJ
AD  - Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, 
      Nanjing 210029.
FAU - Zhang, Ying-Dong
AU  - Zhang YD
FAU - Guan, Qing-Shan
AU  - Guan QS
FAU - Di, Qing
AU  - Di Q
FAU - Shi, Jing-Ping
AU  - Shi JP
FAU - Liu, Wei-Guo
AU  - Liu WG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med Sci J
JT  - Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
JID - 9112559
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Lipoproteins)
RN  - 0 (Resistin)
RN  - 0 (Triglycerides)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Glucose/metabolism
MH  - Cerebral Infarction/blood/genetics
MH  - Creatinine/blood
MH  - Female
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance/*physiology
MH  - Intracranial Arteriosclerosis/blood/genetics
MH  - Lipoproteins/blood
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Resistin/*blood/*genetics
MH  - Stroke/*blood/*genetics
MH  - Triglycerides/blood
EDAT- 2007/04/20 09:00
MHDA- 2009/04/25 09:00
CRDT- 2007/04/20 09:00
PHST- 2007/04/20 09:00 [pubmed]
PHST- 2009/04/25 09:00 [medline]
PHST- 2007/04/20 09:00 [entrez]
PST - ppublish
SO  - Chin Med Sci J. 2007 Mar;22(1):27-32.