PMID- 17441421
OWN - NLM
STAT- MEDLINE
DCOM- 20110505
LR  - 20161124
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 21
IP  - 3
DP  - 2007 Feb
TI  - [Clinical significance and expression of FLIP and PTEN protein in laryngeal 
      squamous cell carcinoma].
PG  - 103-6
AB  - OBJECTIVE: To investigate the expression of FLIP and PTEN in laryngeal Squamous 
      cell carcinoma (LSCC), and the relationship between FLIP and PTEN. METHOD: The 
      protein expression of FLIP and PTEN were examined by using immunohistochemical 
      method in 45 cases of LSCC and 15 cases of para-carcinoma tissues. RESULT: FLIP 
      protein positive expressive rate in the laryngeal squamous cell carcinoma cases 
      (77.8%) was higher than that in the para-carcinoma tissues cases (33.3%, P < 
      0.05). The protein expression of FLIP was correlated with cervical lymph node 
      metastasis, clinical stage and prognosis. On the other hand, PTEN positive 
      expressive rate in the laryngeal squamous cell carcinoma (65.0%) was higher than 
      that in the para-carcinoma tissues (0%, P < 0.01). The protein expression of PTEN 
      was associated with tumor differentiation grade, clinical stage, cervical lymph 
      node metastasis and prognosis. There was a negative relationship between the 
      expression of FLIP and PTEN in LSCC. CONCLUSION: The protein expression of FLIP 
      may be an important prognostic marker for LSCC. The protein expression of PTEN 
      was correlated with clinical stage, tumor differentiation grade, and cervical 
      lymph node metastasis . Consequently, it could be used as a valuable marker for 
      the prognosis of LSCC.
FAU - Wei, Zhenxing
AU  - Wei Z
AD  - Department of Otolaryngology, Zhongnan Hospital of Wuhan University, Wuhan, 
      China. wzxmax2005@yahoo.com.cn
FAU - Jiang, Xiaoqing
AU  - Jiang X
FAU - Zhou, Xuhong
AU  - Zhou X
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (CASP8 and FADD-Like Apoptosis Regulating Protein)
RN  - 0 (CFLAR protein, human)
RN  - EC 3.1.3.67 (PTEN Phosphohydrolase)
RN  - EC 3.1.3.67 (PTEN protein, human)
SB  - IM
MH  - CASP8 and FADD-Like Apoptosis Regulating Protein/*metabolism
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Neoplasm Staging
MH  - PTEN Phosphohydrolase/*metabolism
MH  - Prognosis
EDAT- 2007/04/20 09:00
MHDA- 2011/05/06 06:00
CRDT- 2007/04/20 09:00
PHST- 2007/04/20 09:00 [pubmed]
PHST- 2011/05/06 06:00 [medline]
PHST- 2007/04/20 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007 Feb;21(3):103-6.