PMID- 17441797
OWN - NLM
STAT- MEDLINE
DCOM- 20070717
LR  - 20220310
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 62
IP  - 5
DP  - 2007 May
TI  - Evaluation of the IgE cross-reactions among vespid venoms. A possible approach 
      for the choice of immunotherapy.
PG  - 561-4
AB  - BACKGROUND: Hymenoptera venom allergy can be effectively cured with specific 
      immunotherapy, thus the correct identification of the allergen is essential. In 
      the case of multiple skin and serum positivities it is important to know if a 
      cross-reaction among venoms is present. We studied by CAP-inhibition assays the 
      degree of cross-reactivity between Vespula vulgaris and Polistes dominulus. 
      METHODS: Serum samples were obtained from consecutive patients with a clinical 
      history of grade III-IV reactions to hymenoptera sting and with nondiscriminative 
      skin/CAP positivity to both Vespula and Polistes. Inhibition assays were carried 
      out with a CAP method, incubating the sera separately with both venoms and 
      subsequently measuring the specific immunoglobulin E (IgE) to venoms themselves. 
      RESULTS: Forty-five patients (33 male, mean age 40 years, age range 12-74, total 
      serum IgE 242 +/- 168 kU/l) were included. Their specific IgE to Vespula and 
      Polistes were 12.03 +/- 5.70 kU/l and 10.7 +/- 2.0 kU/l (P = NS), respectively. 
      At the CAP-inhibition assays, in 25 patients a >75% heterologous inhibition by P. 
      dominulus venom against V. vulgaris-specific IgE was found. In six subjects V. 
      vulgaris venom effectively inhibited the P. dominulus-specific IgE. In the 
      remaining 14 cases the CAP-inhibition test provided intermediate and not 
      discriminative results. CONCLUSION: In 31/45 patients, the double sensitizations 
      to venoms were probably the result of cross-reactions and the CAP-inhibition 
      allowed identifying the true double sensitizations. This approach may be helpful 
      for the correct prescription of immunotherapy in the case of V. vulgaris and P. 
      dominulus double positivity.
FAU - Caruso, B
AU  - Caruso B
AD  - Laboratory of Clinical Chemistry and Haematology, Verona General Hospital, 
      Verona, Italy.
FAU - Bonadonna, P
AU  - Bonadonna P
FAU - Severino, M G
AU  - Severino MG
FAU - Manfredi, M
AU  - Manfredi M
FAU - Dama, A
AU  - Dama A
FAU - Schiappoli, M
AU  - Schiappoli M
FAU - Rizzotti, P
AU  - Rizzotti P
FAU - Senna, G
AU  - Senna G
FAU - Passalacqua, G
AU  - Passalacqua G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Wasp Venoms)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Cross Reactions
MH  - *Desensitization, Immunologic
MH  - Female
MH  - Humans
MH  - Hypersensitivity/immunology/*therapy
MH  - Immunoglobulin E/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Species Specificity
MH  - Wasp Venoms/*immunology/*metabolism/therapeutic use
EDAT- 2007/04/20 09:00
MHDA- 2007/07/18 09:00
CRDT- 2007/04/20 09:00
PHST- 2007/04/20 09:00 [pubmed]
PHST- 2007/07/18 09:00 [medline]
PHST- 2007/04/20 09:00 [entrez]
AID - ALL1353 [pii]
AID - 10.1111/j.1398-9995.2007.01353.x [doi]
PST - ppublish
SO  - Allergy. 2007 May;62(5):561-4. doi: 10.1111/j.1398-9995.2007.01353.x.