PMID- 17442753
OWN - NLM
STAT- MEDLINE
DCOM- 20070620
LR  - 20240322
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 104
IP  - 18
DP  - 2007 May 1
TI  - Coherent neural representation of hand speed in humans revealed by MEG imaging.
PG  - 7676-81
AB  - The spiking activity of single neurons in the primate motor cortex is correlated 
      with various limb movement parameters, including velocity. Recent findings 
      obtained using local field potentials suggest that hand speed may also be encoded 
      in the summed activity of neuronal populations. At this macroscopic level, the 
      motor cortex has also been shown to display synchronized rhythmic activity 
      modulated by motor behavior. Yet whether and how neural oscillations might be 
      related to limb speed control is still poorly understood. Here, we applied 
      magnetoencephalography (MEG) source imaging to the ongoing brain activity in 
      subjects performing a continuous visuomotor (VM) task. We used coherence and 
      phase synchronization to investigate the coupling between the estimated activity 
      throughout the brain and the simultaneously recorded instantaneous hand speed. We 
      found significant phase locking between slow (2- to 5-Hz) oscillatory activity in 
      the contralateral primary motor cortex and time-varying hand speed. In addition, 
      we report long-range task-related coupling between primary motor cortex and 
      multiple brain regions in the same frequency band. The detected large-scale VM 
      network spans several cortical and subcortical areas, including structures of the 
      frontoparietal circuit and the cerebello-thalamo-cortical pathway. These findings 
      suggest a role for slow coherent oscillations in mediating neural representations 
      of hand kinematics in humans and provide further support for the putative role of 
      long-range neural synchronization in large-scale VM integration. Our findings are 
      discussed in the context of corticomotor communication, distributed motor 
      encoding, and possible implications for brain-machine interfaces.
FAU - Jerbi, Karim
AU  - Jerbi K
AD  - Cognitive Neuroscience and Brain Imaging Laboratory, Centre National de la 
      Recherche Scientifique, UPR-640 Lena, MEG Center, Universite Pierre et Marie 
      Curie (Paris 6), Hopital de la Salpetriere, 75013 Paris, France. 
      karim.jerbi@lyon.inserm.fr
FAU - Lachaux, Jean-Philippe
AU  - Lachaux JP
FAU - N'Diaye, Karim
AU  - N'Diaye K
FAU - Pantazis, Dimitrios
AU  - Pantazis D
FAU - Leahy, Richard M
AU  - Leahy RM
FAU - Garnero, Line
AU  - Garnero L
FAU - Baillet, Sylvain
AU  - Baillet S
LA  - eng
GR  - R01 EB002010/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070418
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
SB  - IM
MH  - Brain
MH  - Hand/*physiology
MH  - Humans
MH  - Magnetoencephalography
MH  - Male
MH  - Movement/*physiology
MH  - Neurons/*physiology
MH  - Time Factors
PMC - PMC1863498
COIS- The authors declare no conflict of interest.
EDAT- 2007/04/20 09:00
MHDA- 2007/06/21 09:00
PMCR- 2007/11/01
CRDT- 2007/04/20 09:00
PHST- 2007/04/20 09:00 [pubmed]
PHST- 2007/06/21 09:00 [medline]
PHST- 2007/04/20 09:00 [entrez]
PHST- 2007/11/01 00:00 [pmc-release]
AID - 0609632104 [pii]
AID - 5932 [pii]
AID - 10.1073/pnas.0609632104 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2007 May 1;104(18):7676-81. doi: 
      10.1073/pnas.0609632104. Epub 2007 Apr 18.