PMID- 17443102
OWN - NLM
STAT- MEDLINE
DCOM- 20070620
LR  - 20101118
IS  - 1558-2027 (Print)
IS  - 1558-2027 (Linking)
VI  - 8
IP  - 5
DP  - 2007 May
TI  - Edge-to-edge mitral valve repair for isolated prolapse of the anterior leaflet 
      caused by degenerative disease.
PG  - 354-8
AB  - OBJECTIVE: The use of new techniques to correct mitral regurgitation due to 
      prolapse of the anterior leaflet has been shown to expand the original surgical 
      armamentarium and to improve postoperative outcome. We retrospectively analysed 
      our experience with isolated prolapse of the anterior mitral leaflet repaired 
      using the edge-to-edge technique. METHODS: From October 1986 to June 2004, 790 
      patients underwent mitral valve repair for mitral regurgitation at our 
      institution. Isolated pathology of the anterior mitral leaflet, due to 
      degenerative disease, was the cause of mitral regurgitation in 84 patients and, 
      from 1991, 68 underwent edge-to-edge repair. RESULTS: There was no intraoperative 
      death and one in-hospital death. Three patients died in the late follow-up period 
      for a cumulative 13-year survival rate of 90 +/- 1.4%. No patient underwent early 
      reoperation. Four patients underwent reoperation during the follow-up for a 
      cumulative 13-year freedom from reoperation of 92.3 +/- 3.2%. At 
      echocardiographic evaluation, mitral valve repair failure was associated with 
      severe mitral regurgitation in four patients. Of the remaining 60 patients, 40 
      had no residual regurgitation, 18 had trivial residual regurgitation, and two had 
      mild regurgitation. At follow-up, 49 patients are still in New York Heart 
      Association (NYHA) class I, 14 in NYHA class II and only one in NYHA class III. 
      CONCLUSIONS: Our study demonstrates that the 'edge-to-edge' technique is a 
      reliable procedure to correct prolapsing leaflets. The addition of this technique 
      to the surgical armamentarium has neutralized prolapse of the anterior leaflet as 
      an incremental risk factor for reoperation.
FAU - Fucci, Carlo
AU  - Fucci C
AD  - Operative Unit of Cardiac Surgery, Brescia, Italy. carlofucci@libero.it
FAU - Cicco, Giuseppe De
AU  - Cicco GD
FAU - Chiari, Ermanna
AU  - Chiari E
FAU - Nardi, Matilde
AU  - Nardi M
FAU - Faggiano, Pompilio
AU  - Faggiano P
FAU - Procopio, Roberto
AU  - Procopio R
FAU - Coletti, Giuseppe
AU  - Coletti G
FAU - Rambaldini, Manfredo
AU  - Rambaldini M
FAU - Lorusso, Roberto
AU  - Lorusso R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Cardiovasc Med (Hagerstown)
JT  - Journal of cardiovascular medicine (Hagerstown, Md.)
JID - 101259752
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Cardiac Surgical Procedures/adverse effects
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Marfan Syndrome/*complications/surgery
MH  - Middle Aged
MH  - Mitral Valve/pathology/*surgery
MH  - Mitral Valve Insufficiency/etiology/mortality/*surgery
MH  - Mitral Valve Prolapse/*complications/surgery
MH  - Reoperation
MH  - Retrospective Studies
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2007/04/20 09:00
MHDA- 2007/06/21 09:00
CRDT- 2007/04/20 09:00
PHST- 2007/04/20 09:00 [pubmed]
PHST- 2007/06/21 09:00 [medline]
PHST- 2007/04/20 09:00 [entrez]
AID - 01244665-200705000-00009 [pii]
AID - 10.2459/01.JCM.0000268120.45303.cf [doi]
PST - ppublish
SO  - J Cardiovasc Med (Hagerstown). 2007 May;8(5):354-8. doi: 
      10.2459/01.JCM.0000268120.45303.cf.