PMID- 17445151 OWN - NLM STAT- MEDLINE DCOM- 20070621 LR - 20081121 IS - 0001-2815 (Print) IS - 0001-2815 (Linking) VI - 69 Suppl 1 DP - 2007 Apr TI - Overview of registries, HLA typing and diversity, and search algorithms. PG - 3-5 AB - Over 10 million volunteer donors and cord blood units are typed for human leukocyte antigen (HLA) within hematopoietic stem cell registries and cord blood banks. Identification of matched donors in countries different from that of the searching patient is facilitated by Bone Marrow Donors Worldwide and the World Marrow Donor Association (WMDA). A survey of new volunteer donor typing among WMDA member registries has identified the methods and resolution of HLA testing and the level of quality control used to evaluate the accuracy of typing results. The diversity of HLA assignments within registries has generated a number of informatics challenges. Registries are using population genetics to enhance registry diversity and to facilitate the identification of matched donors. FAU - Hurley, C K AU - Hurley CK AD - Georgetown University, Washington, DC 20057, USA. hurleyc@georgetown.edu FAU - Maiers, M AU - Maiers M FAU - Marsh, S G E AU - Marsh SG FAU - Oudshoorn, M AU - Oudshoorn M LA - eng PT - Journal Article PT - Review PL - England TA - Tissue Antigens JT - Tissue antigens JID - 0331072 RN - 0 (HLA Antigens) SB - IM MH - *Algorithms MH - *Genetic Variation MH - HLA Antigens/classification/*genetics MH - Histocompatibility Testing/*methods MH - Humans MH - *Registries MH - Tissue Donors/*supply & distribution RF - 0 EDAT- 2007/04/21 09:00 MHDA- 2007/06/22 09:00 CRDT- 2007/04/21 09:00 PHST- 2007/04/21 09:00 [pubmed] PHST- 2007/06/22 09:00 [medline] PHST- 2007/04/21 09:00 [entrez] AID - TAN758_2 [pii] AID - 10.1111/j.1399-0039.2006.758_2.x [doi] PST - ppublish SO - Tissue Antigens. 2007 Apr;69 Suppl 1:3-5. doi: 10.1111/j.1399-0039.2006.758_2.x.