PMID- 17445160
OWN - NLM
STAT- MEDLINE
DCOM- 20070621
LR  - 20111117
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69 Suppl 1
DP  - 2007 Apr
TI  - Clinical importance of HLA-DPB1 in haematopoietic cell transplantation.
PG  - 36-41
AB  - There is increasing evidence for a significant effect of human leukocyte antigen 
      (HLA)-DPB1 mismatching on complications following unrelated donor haematopoietic 
      cell transplantation (HCT). In this analysis of 5930 patient/donor pairs, we 
      found that a DPB1 mismatch predicted significantly for an increased risk of acute 
      graft-vs-host disease [hazard ratio (HR): 1.33; P-value = <0.0001], while 
      protecting against disease relapse (HR: 0.82, P-value = 0.01). These data support 
      an immunogenic role for HLA-DPB1 in HCT and the need for pretransplant tissue 
      typing at this locus.
FAU - Shaw, B E
AU  - Shaw BE
AD  - Department of Haematology, Nottingham City Hospital, Nottingham, UK. 
      bshaw@doctors.org.uk
FAU - Gooley, T
AU  - Gooley T
FAU - Madrigal, J A
AU  - Madrigal JA
FAU - Malkki, M
AU  - Malkki M
FAU - Marsh, S G E
AU  - Marsh SG
FAU - Petersdorf, E W
AU  - Petersdorf EW
LA  - eng
GR  - AI 49213/AI/NIAID NIH HHS/United States
GR  - AI069197/AI/NIAID NIH HHS/United States
GR  - AI33484/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
SB  - IM
MH  - Female
MH  - Graft vs Host Disease/immunology
MH  - HLA-DP Antigens/genetics/*immunology
MH  - HLA-DP beta-Chains
MH  - Hematologic Neoplasms/immunology/*therapy
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Male
MH  - Neoplasm Recurrence, Local/etiology/therapy
MH  - Predictive Value of Tests
MH  - Survival Rate
EDAT- 2007/04/21 09:00
MHDA- 2007/06/22 09:00
CRDT- 2007/04/21 09:00
PHST- 2007/04/21 09:00 [pubmed]
PHST- 2007/06/22 09:00 [medline]
PHST- 2007/04/21 09:00 [entrez]
AID - TAN759_4 [pii]
AID - 10.1111/j.1399-0039.2006.759_4.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Apr;69 Suppl 1:36-41. doi: 
      10.1111/j.1399-0039.2006.759_4.x.