PMID- 17445178
OWN - NLM
STAT- MEDLINE
DCOM- 20070621
LR  - 20220330
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69 Suppl 1
DP  - 2007 Apr
TI  - Modelling KIR-HLA genotype disparities in type 1 diabetes.
PG  - 101-5
AB  - We previously reported that a disparate distribution between killer cell 
      immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA) class 1 
      genes is associated with susceptibility to develop type 1 diabetes. Here we 
      compare multiple models which reflect the combined genotype effects of 
      combinations of functional inhibitory and activating KIRs in relation to HLA in 
      an extended cohort of patients with juvenile-onset type 1 diabetes and 
      non-diabetic control subjects. Our results suggest that autoimmunity in type 1 
      diabetes is mainly associated with a decrease in inhibitory KIR-HLA genotype 
      combinations, while the influence of activating KIR genotypes seems redundant. 
      However, logistic regression showed that activating KIR genotypes do influence 
      the overall hierarchy of protection/susceptibility as reflected by composite 
      inhibitory and activating KIR-HLA genotype models.
FAU - van der Slik, A R
AU  - van der Slik AR
AD  - Department of Immunohaematology & Blood Transfusion, Leiden University Medical 
      Center, Leiden, The Netherlands.
FAU - Alizadeh, B Z
AU  - Alizadeh BZ
FAU - Koeleman, B P C
AU  - Koeleman BP
FAU - Roep, B O
AU  - Roep BO
FAU - Giphart, M J
AU  - Giphart MJ
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Killer Cells, Natural/immunology
MH  - *Models, Biological
MH  - Receptors, Immunologic/*genetics/immunology
MH  - Receptors, KIR
EDAT- 2007/04/21 09:00
MHDA- 2007/06/22 09:00
CRDT- 2007/04/21 09:00
PHST- 2007/04/21 09:00 [pubmed]
PHST- 2007/06/22 09:00 [medline]
PHST- 2007/04/21 09:00 [entrez]
AID - TAN762_5 [pii]
AID - 10.1111/j.1399-0039.2006.762_5.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Apr;69 Suppl 1:101-5. doi: 
      10.1111/j.1399-0039.2006.762_5.x.