PMID- 17445179
OWN - NLM
STAT- MEDLINE
DCOM- 20070621
LR  - 20220331
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69 Suppl 1
DP  - 2007 Apr
TI  - KIRs and autoimmune disease: studies in systemic lupus erythematosus and 
      scleroderma.
PG  - 106-8
AB  - We investigated killer immunoglobulin-like receptors (KIRs) and the human 
      leukocyte antigen (HLA)-C ligands for the corresponding inhibitory KIRs in 
      Caucasian patients, 304 with systemic lupus erythematosus (SLE) and 90 with 
      scleroderma [or progressive systemic sclerosis (PSS)] compared with 416 Caucasian 
      controls. Compared with controls, KIR2DS1 in the absence of KIR2DS2 was increased 
      in both SLE (P= 0.04) and PSS (P= 0.02). Only 42% of KIR2DS1-positive PSS 
      patients had the appropriate HLA-C ligand for the corresponding inhibitory KIR 
      compared with 61% of KIR2DS1 positive controls (P= 0.02). In the PSS group the 
      presence of at least either activating KIR2DS1 and/or 2DS2 was significantly 
      increased in patients when compared with controls (P= 0.001). This suggests that 
      KIR receptors play a role in susceptibility to both PSS and SLE.
FAU - Pellett, F
AU  - Pellett F
AD  - HLA laboratory, Toronto Western Research Institute, Toronto, Ontario, Canada.
FAU - Siannis, F
AU  - Siannis F
FAU - Vukin, I
AU  - Vukin I
FAU - Lee, P
AU  - Lee P
FAU - Urowitz, M B
AU  - Urowitz MB
FAU - Gladman, D D
AU  - Gladman DD
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (KIR2DS1 protein, human)
RN  - 0 (KIR2DS2 protein, human)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Cadaver
MH  - Case-Control Studies
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Killer Cells, Natural/immunology
MH  - Lupus Erythematosus, Systemic/*genetics
MH  - Prospective Studies
MH  - Receptors, Immunologic/*genetics
MH  - Receptors, KIR
MH  - Scleroderma, Diffuse/*genetics
MH  - Tissue Donors
EDAT- 2007/04/21 09:00
MHDA- 2007/06/22 09:00
CRDT- 2007/04/21 09:00
PHST- 2007/04/21 09:00 [pubmed]
PHST- 2007/06/22 09:00 [medline]
PHST- 2007/04/21 09:00 [entrez]
AID - TAN762_6 [pii]
AID - 10.1111/j.1399-0039.2006.762_6.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Apr;69 Suppl 1:106-8. doi: 
      10.1111/j.1399-0039.2006.762_6.x.