PMID- 17445185
OWN - NLM
STAT- MEDLINE
DCOM- 20070621
LR  - 20211203
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69 Suppl 1
DP  - 2007 Apr
TI  - Distribution of the killer cell immunoglobulin-like receptors in Mexican 
      Mestizos.
PG  - 125-9
AB  - Understanding the complex interaction between human leukocyte antigen (HLA) and 
      killer immunoglobulin-like receptor (KIR) requires study of both HLA and KIR 
      diversity in the same population. The presence of KIR genes 2DL1, 2, 3, 4, 5, 
      KIR3DL1, 3DL2, 3DL3, KIR2DS1, 2DS2, 2DS3, 2DS4, 2DS5, KIR3DS1, KIR3DP1, KIR2DP1 
      was determined in 54 unrelated Mexican Mestizo donors. The PCR sequence-specific 
      oligonucleotide probe One Lambda kit (Luminex) kindly given by J. Lee was used 
      for typing. The software analyses the combination obtained for each of the five 
      exons. Five controls (UCLA DNA exchange) were run as quality control. The gene 
      frequency (GF) was calculated for the 16 KIR loci; the GF of individual genes was 
      100% for 2DL4, 3DL1, 3DL2, 3DL3, 3DP1. KIR2DL1 (76.43%), KIR2DL2 (37.64%), 
      KIR2DL3 (76.43%), KIR2DL5 (29.29%), KIR3DS1 (23.02%), KIR2DS1 (21.83%), KIR2DS2 
      (37.64%), KIR2DS3 (50.93%), KIR2DS4 (86.93%), KIR2DS5 (29.29%), KIR2DP1 (86.39%). 
      We observed similar frequencies with Caucasians and Mediterraneans, with 
      exceptions: KIR3DL1 which was present in 100% Mexicans, ranged from 62% to 75% in 
      Caucasians; 2DS3 (50.9%) vs 14-20% 2DS4 (86.39%) vs 65-79% and 2DS5 (29.29%) vs 
      11-18% in Caucasians. The finding of 23 phenotypes in 54 individuals accounting 
      for both chromosomes, demonstrates the enormous diversity. We found 14 different 
      combinations of stimulatory KIRs in the phenotypes; every subject had at least 
      one stimulatory KIR; in all of them, 2DS4 existed except for one person who may 
      have some new combination: 2DS2 2DS3. Extended family data will offer accurate 
      and precise haplotypes to provide an insight on the significance of ethnic 
      distribution and KIR repertoire.
FAU - Contreras, G
AU  - Contreras G
AD  - Department of Immunology & Immunogenetics, Instituto de Diagnostico y Referencia 
      Epidemiologicos, InDRE, Secretary of Health, Mexico City, Mexico.
FAU - Alaez, C
AU  - Alaez C
FAU - Murguia, A
AU  - Murguia A
FAU - Garcia, D
AU  - Garcia D
FAU - Flores, H
AU  - Flores H
FAU - Gorodezky, C
AU  - Gorodezky C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (KIR2DL2 protein, human)
RN  - 0 (KIR2DL3 protein, human)
RN  - 0 (KIR3DL1 protein, human)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, KIR)
RN  - 0 (Receptors, KIR2DL1)
RN  - 0 (Receptors, KIR2DL2)
RN  - 0 (Receptors, KIR2DL3)
RN  - 0 (Receptors, KIR2DL4)
RN  - 0 (Receptors, KIR3DL1)
RN  - 0 (Receptors, KIR3DL2)
RN  - 0 (Receptors, KIR3DS1)
SB  - IM
MH  - Ethnicity/*genetics
MH  - Gene Frequency
MH  - Genetics, Population
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Killer Cells, Natural/*immunology
MH  - Mexico/ethnology
MH  - Phenotype
MH  - *Polymorphism, Genetic
MH  - Receptors, Immunologic/classification/*genetics/immunology
MH  - Receptors, KIR
MH  - Receptors, KIR2DL1
MH  - Receptors, KIR2DL2
MH  - Receptors, KIR2DL3
MH  - Receptors, KIR2DL4
MH  - Receptors, KIR3DL1
MH  - Receptors, KIR3DL2
MH  - Receptors, KIR3DS1
EDAT- 2007/04/21 09:00
MHDA- 2007/06/22 09:00
CRDT- 2007/04/21 09:00
PHST- 2007/04/21 09:00 [pubmed]
PHST- 2007/06/22 09:00 [medline]
PHST- 2007/04/21 09:00 [entrez]
AID - TAN76212 [pii]
AID - 10.1111/j.1399-0039.2006.76212.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Apr;69 Suppl 1:125-9. doi: 
      10.1111/j.1399-0039.2006.76212.x.