PMID- 17445188
OWN - NLM
STAT- MEDLINE
DCOM- 20070621
LR  - 20111117
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69 Suppl 1
DP  - 2007 Apr
TI  - MHC-F polymorphism and evolution.
PG  - 136-9
AB  - The major histocompatibility complex (MHC)-F class Ib locus shows a limited 
      polymorphism, and the function of its mainly intracellular protein is not clear. 
      We have identified human leukocyte antigen (HLA)-F orthologous DNA sequences in 
      Pongidae in order to study the MHC-F gene evolution and its products' function. 
      HLA-F orthologous complementary DNA transcripts are found in chimpanzee and in 
      the new primate species studied (bonobo, gorilla and orangutan). Analyses of the 
      predicted amino acid sequences and their comparison with other primate MHC-F 
      proteins show that MHC-F may be a protein with a typical class I structure and 
      that the key residues of the peptide-binding region are highly conserved in MHC-F 
      in all studied primates species. Thus, MHC-F conservation along the primate 
      evolution suggests an important role in cellular physiology. It is possible that 
      the MHC-F protein could be involved, together with MHC-G and MHC-E, in the 
      natural killer cell activity regulation, although rhesus macaque cannot express 
      complete surface MHC-G orthologue molecules.
FAU - Moscoso, J
AU  - Moscoso J
AD  - Department of Immunology, The Madrid Regional Blood Center, Universidad 
      Complutense, Madrid, Spain.
FAU - Serrano-Vela, J Ignacio
AU  - Serrano-Vela JI
FAU - Arnaiz-Villena, A
AU  - Arnaiz-Villena A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-F antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Animals
MH  - *Biological Evolution
MH  - Genes, MHC Class I/*genetics
MH  - HLA Antigens/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - *Polymorphism, Genetic
MH  - Primates/*genetics
MH  - Protein Conformation
EDAT- 2007/04/21 09:00
MHDA- 2007/06/22 09:00
CRDT- 2007/04/21 09:00
PHST- 2007/04/21 09:00 [pubmed]
PHST- 2007/06/22 09:00 [medline]
PHST- 2007/04/21 09:00 [entrez]
AID - TAN763_3 [pii]
AID - 10.1111/j.1399-0039.2006.763_3.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Apr;69 Suppl 1:136-9. doi: 
      10.1111/j.1399-0039.2006.763_3.x.