PMID- 17445193 OWN - NLM STAT- MEDLINE DCOM- 20070621 LR - 20111117 IS - 0001-2815 (Print) IS - 0001-2815 (Linking) VI - 69 Suppl 1 DP - 2007 Apr TI - HLA-G polymorphism and evolution. PG - 156-9 AB - Six proteins, one null allele and 22 human leukocyte antigen (HLA)-G alleles were found in humans. Bonobo, chimpanzee and gorilla only show one allele and orangutan shows five alleles. All Cercopithecus alleles show stop codons at position 164 (Macaca mulatta with seven DNA alleles, Macaca fascicularis with seven DNA alleles and Cercopithecus aethiops with three DNA alleles). Cotton-top tamarin New World monkeys showed 20 DNA and protein alleles; the major histocompatibility complex (MHC)-G New World sequences seem to be closer to MHC-E and lack typical MHC-G primates intron 2-specific deletion. This seems to suggest that MHC-G genes in New World primates are not orthologous and that their function may be similar to that of classical presenting MHC genes. FAU - Arnaiz-Villena, A AU - Arnaiz-Villena A AD - Department of Immunology, The Madrid Regional Blood Center, Universidad Complutense, Madrid, Spain. aarnaiz@med.ucm.es FAU - Martinez-Laso, J AU - Martinez-Laso J FAU - Serrano-Vela, J I AU - Serrano-Vela JI FAU - Reguera, R AU - Reguera R FAU - Moscoso, J AU - Moscoso J LA - eng PT - Journal Article PL - England TA - Tissue Antigens JT - Tissue antigens JID - 0331072 RN - 0 (HLA Antigens) RN - 0 (HLA-G Antigens) RN - 0 (Histocompatibility Antigens Class I) SB - IM MH - Animals MH - Base Sequence MH - *Biological Evolution MH - Family MH - Female MH - HLA Antigens/*genetics MH - HLA-G Antigens MH - Histocompatibility Antigens Class I/*genetics MH - Homozygote MH - Humans MH - Major Histocompatibility Complex/*genetics/immunology MH - Male MH - Molecular Sequence Data MH - Pedigree MH - *Polymorphism, Genetic MH - Primates/genetics MH - Sequence Homology, Nucleic Acid EDAT- 2007/04/21 09:00 MHDA- 2007/06/22 09:00 CRDT- 2007/04/21 09:00 PHST- 2007/04/21 09:00 [pubmed] PHST- 2007/06/22 09:00 [medline] PHST- 2007/04/21 09:00 [entrez] AID - TAN763_8 [pii] AID - 10.1111/j.1399-0039.2006.763_8.x [doi] PST - ppublish SO - Tissue Antigens. 2007 Apr;69 Suppl 1:156-9. doi: 10.1111/j.1399-0039.2006.763_8.x.