PMID- 17445195
OWN - NLM
STAT- MEDLINE
DCOM- 20070621
LR  - 20070420
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69 Suppl 1
DP  - 2007 Apr
TI  - 14th International HLA and Immunogenetics Workshop: report on the Prospective 
      Chronic Rejection Project.
PG  - 174-9
AB  - An international collaborative study of 45 transplant centers was undertaken at 
      the 14th International HLA (human leukocyte antigen) and Immunogenetics Workshop 
      to see if HLA antibodies detected posttransplant are predictive of chronic graft 
      failure. With the newly developed assay, MICA (major histocompatibility complex 
      class I-related chain A) antibodies were also measured and their effect analyzed. 
      Total of 5219 sera from patients who were more than 6 months posttransplant with 
      functioning graft were tested for HLA antibodies by enzyme-linked immunosorbent 
      assay, flow cytometry, or Luminex. HLA antibodies were found in 27.2% of kidney 
      patients, 23.6% in the liver, 52.7% in the heart, and 21.7% in the lung. The 
      method of antibody testing did not have a marked influence on the frequency of 
      antibodies detected. MICA antibodies were detected in 15% of kidney patients, 30% 
      of heart patients, and 31% of liver patients. Among 948 kidney patients who had 
      HLA antibodies, 7.3% had rejected their graft within 1 year of testing, compared 
      with 1.7% in 2615 patients without HLA antibodies (P= 0.8 x 10(-17)). Death 
      occurred in 1.4% of total kidney patients and did not correlate to the presence 
      of antibodies. We conclude that patients with posttransplant HLA antibodies 
      indeed have a higher rate of chronic graft failure and that posttransplant 
      antibodies are predictive of chronic rejection.
FAU - Ozawa, M
AU  - Ozawa M
AD  - One Lambda, Inc., Los Angeles, CA, USA. mozawa@terasakilab.org
FAU - Terasaki, P I
AU  - Terasaki PI
FAU - Lee, J H
AU  - Lee JH
FAU - Castro, R
AU  - Castro R
FAU - Alberu, J
AU  - Alberu J
FAU - Alonso, C
AU  - Alonso C
FAU - Alvarez, I
AU  - Alvarez I
FAU - Toledo, R
AU  - Toledo R
FAU - Alvez, H
AU  - Alvez H
FAU - Monterio, M
AU  - Monterio M
FAU - Teixeira, J
AU  - Teixeira J
FAU - Campbell, P
AU  - Campbell P
FAU - Ciszek, M
AU  - Ciszek M
FAU - Charron, D
AU  - Charron D
FAU - Gautreau, C
AU  - Gautreau C
FAU - Christiansen, F
AU  - Christiansen F
FAU - Conca, R
AU  - Conca R
FAU - Gomez, B
AU  - Gomez B
FAU - Monteon, F
AU  - Monteon F
FAU - Grosse-Wilde, H
AU  - Grosse-Wilde H
FAU - Heinemann, F
AU  - Heinemann F
FAU - Humar, I
AU  - Humar I
FAU - Kamoun, M
AU  - Kamoun M
FAU - Kimball, P
AU  - Kimball P
FAU - Kobayashi, T
AU  - Kobayashi T
FAU - Kupatawintu, P
AU  - Kupatawintu P
FAU - Leech, S
AU  - Leech S
FAU - LeFor, W
AU  - LeFor W
FAU - Mehra, N
AU  - Mehra N
FAU - Panigrahi, A
AU  - Panigrahi A
FAU - Naumova, E
AU  - Naumova E
FAU - Norman, D
AU  - Norman D
FAU - Piazza, A
AU  - Piazza A
FAU - Poli, F
AU  - Poli F
FAU - Colombo, B
AU  - Colombo B
FAU - Roy, R
AU  - Roy R
FAU - Schonemann, C
AU  - Schonemann C
FAU - Sireci, G
AU  - Sireci G
FAU - Tanabe, K
AU  - Tanabe K
FAU - Ishida, H
AU  - Ishida H
FAU - Van den Berg-Loonen, E
AU  - Van den Berg-Loonen E
FAU - Zeevi, A
AU  - Zeevi A
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Chronic Disease
MH  - Graft Rejection/*etiology
MH  - Graft Survival
MH  - HLA Antigens/*immunology
MH  - Heart Transplantation/adverse effects/*immunology
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - *Immunogenetics
MH  - Kidney Transplantation/adverse effects/*immunology
MH  - *Transplantation Immunology
EDAT- 2007/04/21 09:00
MHDA- 2007/06/22 09:00
CRDT- 2007/04/21 09:00
PHST- 2007/04/21 09:00 [pubmed]
PHST- 2007/06/22 09:00 [medline]
PHST- 2007/04/21 09:00 [entrez]
AID - TAN765 [pii]
AID - 10.1111/j.1399-0039.2006.00765.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Apr;69 Suppl 1:174-9. doi: 
      10.1111/j.1399-0039.2006.00765.x.