PMID- 17445197
OWN - NLM
STAT- MEDLINE
DCOM- 20070621
LR  - 20071115
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69 Suppl 1
DP  - 2007 Apr
TI  - 14th International HLA and Immunogenetics Workshop: report of progress in 
      methodology, data collection, and analyses.
PG  - 185-7
AB  - The Biostatistics Component of the 13th International Histocompatibility Workshop 
      (IHWS) developed the PyPop (Python for Population Genomics) software framework 
      for high-throughput analysis and quality control (QC) assessments of highly 
      polymorphic genotype data. Since its initial release, the software has had 
      several new analysis modules added to it. These additions, combined with improved 
      data filtering and QC modules, facilitate analyses of data at different levels 
      (allele, haplotype, amino acid sequence, and nucleotide sequence). Since the 13th 
      IHWS, much of the human leukocyte antigen (HLA) data from the workshop, QCed via 
      PyPop and other methods, have been made publicly available through the Major 
      Histocompatibility Complex database web site at the National Center for 
      Biotechnology Information (http://ncbi.nih.gov/mhc/). The Anthropology/Human 
      Genetic Diversity component (AHGDC) data have been used in a variety of studies. 
      Prugnolle et al. used this data to corroborate a model of pathogen-driven 
      selection as a factor related to high levels of diversity at HLA loci. Using a 
      comparative genomics approach contrasting results for HLA and non-HLA markers, 
      Meyer et al. analyzed a subset of the 13th IHWS AHGDC data and showed that HLA 
      loci show detectable signs of both natural selection and the demographic history 
      of populations.
FAU - Single, R M
AU  - Single RM
AD  - Department of Mathematics and Statistics, University of Vermont, Burlington, VT, 
      USA. Richard.Single@uvm.edu
FAU - Meyer, D
AU  - Meyer D
FAU - Mack, S J
AU  - Mack SJ
FAU - Lancaster, A
AU  - Lancaster A
FAU - Erlich, H A
AU  - Erlich HA
FAU - Thomson, G
AU  - Thomson G
LA  - eng
GR  - AI49213/AI/NIAID NIH HHS/United States
GR  - GM35326/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Data Collection
MH  - *Databases as Topic
MH  - Genetics, Population
MH  - HLA Antigens/*genetics/immunology
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - *Immunogenetics
MH  - Internet
MH  - Major Histocompatibility Complex/*immunology
RF  - 12
EDAT- 2007/04/21 09:00
MHDA- 2007/06/22 09:00
CRDT- 2007/04/21 09:00
PHST- 2007/04/21 09:00 [pubmed]
PHST- 2007/06/22 09:00 [medline]
PHST- 2007/04/21 09:00 [entrez]
AID - TAN767 [pii]
AID - 10.1111/j.1399-0039.2006.00767.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Apr;69 Suppl 1:185-7. doi: 
      10.1111/j.1399-0039.2006.00767.x.