PMID- 17445200
OWN - NLM
STAT- MEDLINE
DCOM- 20070621
LR  - 20081121
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69 Suppl 1
DP  - 2007 Apr
TI  - An apportionment of human HLA diversity.
PG  - 198-202
AB  - In this study, we estimate the amount of human leukocyte antigen (HLA) genetic 
      diversity in the global human population at three levels of population hierarchy: 
      within populations; among populations within continents and among continents on 
      large sets of HLA population data gathered during the last international 
      histocompatibility and immunogenetics workshops and conferences. The results 
      indicate that loci HLA-A, B, C, DRB1, DQA1 and DQB1 exhibit a higher amount of 
      diversity among individuals of the same population than observed for neutral 
      polymorphisms (average diversity of 90.3% compared with 84.4%-87.6% for neutral 
      DNA markers). On the other hand, the value (84%) obtained for HLA-DPB1 is very 
      similar to those observed for non-HLA nuclear markers, in agreement with other 
      results suggesting the neutrality of this locus. In addition to the results of 
      the hierarchical analysis of variance, selective neutrality tests indicate that 
      loci B, C and DRB1 are the most affected by balancing selection. However, one 
      cannot discriminate between a direct selective effect acting on those loci or a 
      general effect of associative overdominance acting over the large HLA region (in 
      linkage disequilibrium) encompassing those loci.
FAU - Sanchez-Mazas, Alicia
AU  - Sanchez-Mazas A
AD  - Laboratory of Anthropology, Genetics and Peopling History AGP, University of 
      Geneva, Geneva, Switzerland. Alicia.sanchez-mazas@anthro.unige.ch
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Alleles
MH  - Gene Frequency
MH  - *Genetic Variation
MH  - HLA Antigens/classification/*genetics
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/classification/*genetics
MH  - Histocompatibility Antigens Class II/classification/*genetics
MH  - Humans
EDAT- 2007/04/21 09:00
MHDA- 2007/06/22 09:00
CRDT- 2007/04/21 09:00
PHST- 2007/04/21 09:00 [pubmed]
PHST- 2007/06/22 09:00 [medline]
PHST- 2007/04/21 09:00 [entrez]
AID - TAN802 [pii]
AID - 10.1111/j.1399-0039.2006.00802.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Apr;69 Suppl 1:198-202. doi: 
      10.1111/j.1399-0039.2006.00802.x.