PMID- 17445204
OWN - NLM
STAT- MEDLINE
DCOM- 20070621
LR  - 20071203
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69 Suppl 1
DP  - 2007 Apr
TI  - 14th International HLA and Immunogenetics Workshop: report on the HLA component 
      of type 1 diabetes.
PG  - 214-25
AB  - The type 1 diabetes (T1D) component of the 13th International Histocompatibility 
      Workshop (IHW) obtained microsatellite (msat) and human leukocyte antigen 
      (HLA)-DR/DQ data on case/control and family samples through an international 
      collaboration. The aim was to detect the effects of susceptibility loci on the 
      HLA complex independent of the primary determinants in the class II region 
      (HLA-DR/DQ). As part of the activity of the 14th International HLA and 
      Immunogenetics Workshop (14th IHIWS), a T1D workshop was held to present analyses 
      of the 13th IHW data and to discuss the current status of knowledge about the 
      genetics of T1D. These data are now available online through dbMHC, a web-based 
      resource established by the National Center for Biotechnology. Continuing work 
      since the 13th IHW has resulted in published work showing heterogeneity of DR3 
      haplotypes in data sets from the 13th IHW and Human Biological Data Interchange 
      (HBDI). In addition, we identified markers that define DRB1*1501 DQB1*0602 
      haplotypes conferring reduced protection from diabetes in a Swedish 13th IHW data 
      set. Further analyses of the 13th IHW data set not only showed some significant 
      results but also demonstrated extensive heterogeneity reminiscent of non-HLA 
      genes. The haplotype analysis in HBDI families identified two msats with 
      significant effects on susceptibility and statistically significant age of onset 
      effects at class III markers that are not because of linkage disequilibrium, with 
      class I alleles known to affect age of onset. The above studies underscore the 
      importance of refining our understanding of susceptibility associated with genes 
      in the HLA complex.
FAU - Steenkiste, A
AU  - Steenkiste A
AD  - Department of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
FAU - Valdes, A M
AU  - Valdes AM
FAU - Feolo, M
AU  - Feolo M
FAU - Hoffman, D
AU  - Hoffman D
FAU - Concannon, P
AU  - Concannon P
FAU - Noble, J
AU  - Noble J
FAU - Schoch, G
AU  - Schoch G
FAU - Hansen, J
AU  - Hansen J
FAU - Helmberg, W
AU  - Helmberg W
FAU - Dorman, J S
AU  - Dorman JS
FAU - Thomson, G
AU  - Thomson G
FAU - Pugliese, A
AU  - Pugliese A
CN  - 13th IHWS 1 Diabetes Component participating investigators
LA  - eng
GR  - DK46632/DK/NIDDK NIH HHS/United States
GR  - DK61722/DK/NIDDK NIH HHS/United States
GR  - GM35326/GM/NIGMS NIH HHS/United States
GR  - U24 AL-49213/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Diabetes Mellitus, Type 1/epidemiology/*genetics/immunology
MH  - Genetic Predisposition to Disease/*epidemiology
MH  - HLA Antigens/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - *Immunogenetics
RF  - 42
EDAT- 2007/04/21 09:00
MHDA- 2007/06/22 09:00
CRDT- 2007/04/21 09:00
PHST- 2007/04/21 09:00 [pubmed]
PHST- 2007/06/22 09:00 [medline]
PHST- 2007/04/21 09:00 [entrez]
AID - TAN772 [pii]
AID - 10.1111/j.1399-0039.2006.00772.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Apr;69 Suppl 1:214-25. doi: 
      10.1111/j.1399-0039.2006.00772.x.