PMID- 17445206
OWN - NLM
STAT- MEDLINE
DCOM- 20070621
LR  - 20070420
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69 Suppl 1
DP  - 2007 Apr
TI  - Immunogenetics of mycobacterial infections in the North Indian population.
PG  - 228-30
AB  - Several lines of evidence highlight the genetic basis of risk to develop 
      mycobacterial diseases. Human leukocyte antigen (HLA)-DR2 alleles (DRB1*1501 and 
      DRB1*1502) have been found to be strongly associated with mycobacterial disease, 
      especially the more severe forms such as lepromatous leprosy and 
      multidrug-resistant pulmonary tuberculosis. In this study, DNA-based 
      high-resolution typing techniques of polymerase chain reaction-sequence-specific 
      oligonucleotide probe were used to determine the distribution of HLA-DR/DQ 
      alleles in patients with leprosy and pulmonary tuberculosis. Analysis of 
      different DR2 subtypes based on valine/glycine dimorphism at codon beta86 in 
      pocket 1 of HLA-DR showed an inverse relationship of DR2 alleles with V/G as the 
      severity of disease increased both in leprosy and in pulmonary tuberculosis.
FAU - Singh, M
AU  - Singh M
AD  - Department of Transplant Immunology & Immunogenetics, All India Institute of 
      Medical Sciences, New Delhi 110029, India.
FAU - Balamurugan, A
AU  - Balamurugan A
FAU - Katoch, K
AU  - Katoch K
FAU - Sharma, S K
AU  - Sharma SK
FAU - Mehra, N K
AU  - Mehra NK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (DNA Primers)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Oligonucleotide Probes)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - DNA Primers
MH  - HLA-DR Antigens/classification/*genetics
MH  - Haplotypes
MH  - Humans
MH  - *Immunogenetics
MH  - India
MH  - Leprosy/genetics/*immunology
MH  - Mycobacterium Infections/genetics/*immunology
MH  - Oligonucleotide Probes
MH  - Polymerase Chain Reaction
MH  - Tuberculosis, Pulmonary/genetics/*immunology
EDAT- 2007/04/21 09:00
MHDA- 2007/06/22 09:00
CRDT- 2007/04/21 09:00
PHST- 2007/04/21 09:00 [pubmed]
PHST- 2007/06/22 09:00 [medline]
PHST- 2007/04/21 09:00 [entrez]
AID - TAN77311 [pii]
AID - 10.1111/j.1399-0039.2006.77311.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Apr;69 Suppl 1:228-30. doi: 
      10.1111/j.1399-0039.2006.77311.x.