PMID- 17445209
OWN - NLM
STAT- MEDLINE
DCOM- 20070621
LR  - 20090626
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69 Suppl 1
DP  - 2007 Apr
TI  - Influence of inhibitory killer immunoglobulin-like receptors and their HLA-C 
      ligands on resolving hepatitis C virus infection.
PG  - 237-40
AB  - An estimated 2%-3% of the world's population is chronically infected with 
      hepatitis C virus (HCV) and this is a major cause of liver disease worldwide. 
      Following acute infection, outcome is variable with acute HCV successfully 
      resolved in some individuals (20%-30%), but in the majority of cases the virus is 
      able to persist. Co-infection with human immunodeficiency virus has been 
      associated with a negative impact on the course of HCV infection. The host's 
      immune response is an important correlate of HCV infection outcome and disease 
      progression. Natural killer (NK) cells provide a major component of the antiviral 
      immune response by recognising and killing virally infected cells. NK cells 
      modulate their activity through a combination of inhibitory and activatory 
      receptors such as the killer immunoglobulin-like receptors (KIRs) that bind to 
      human leukocyte antigen (HLA) Class I molecules. In this workshop component, we 
      addressed the influence of KIR genotypes and their HLA ligands on resolving HCV 
      infection and we discuss the implications of the results of the study of 
      Lopez-Vazquez et al. on KIR and HCV disease progression.
FAU - Rauch, A
AU  - Rauch A
AD  - Klinik und Poliklinik fur Infektiologie, Inselspital Bern, Switzerland.
FAU - Laird, R
AU  - Laird R
FAU - McKinnon, E
AU  - McKinnon E
FAU - Telenti, A
AU  - Telenti A
FAU - Furrer, H
AU  - Furrer H
FAU - Weber, R
AU  - Weber R
FAU - Smillie, D
AU  - Smillie D
FAU - Gaudieri, S
AU  - Gaudieri S
CN  - Swiss HIV Cohort Study
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-C Antigens)
RN  - 0 (Ligands)
RN  - 0 (RNA, Viral)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Alleles
MH  - Female
MH  - HLA-C Antigens/*genetics/immunology/metabolism
MH  - Hepacivirus/physiology
MH  - Hepatitis C/genetics/*immunology/virology
MH  - Humans
MH  - Killer Cells, Natural/*immunology
MH  - Ligands
MH  - Male
MH  - RNA, Viral/genetics
MH  - Receptors, Immunologic/*genetics/metabolism
MH  - Receptors, KIR
EDAT- 2007/04/21 09:00
MHDA- 2007/06/22 09:00
CRDT- 2007/04/21 09:00
PHST- 2007/04/21 09:00 [pubmed]
PHST- 2007/06/22 09:00 [medline]
PHST- 2007/04/21 09:00 [entrez]
AID - TAN773_4 [pii]
AID - 10.1111/j.1399-0039.2006.773_4.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Apr;69 Suppl 1:237-40. doi: 
      10.1111/j.1399-0039.2006.773_4.x.