PMID- 17445215
OWN - NLM
STAT- MEDLINE
DCOM- 20070621
LR  - 20181201
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69 Suppl 1
DP  - 2007 Apr
TI  - Different mechanisms can lead to the same altered HLA class I phenotype in 
      tumors.
PG  - 259-63
AB  - Human leukocyte antigen (HLA) class I plays an important role in tumor 
      recognition and rejection. Total or selective losses of HLA class I antigens 
      (classified into seven HLA class I altered phenotypes) represent one of the main 
      routes of tumor escape from immune surveillance. Abnormal expression of HLA class 
      I has been reported in different human tumor samples with distinct underlying 
      mechanisms. Notably, different molecular mechanisms can generate the same altered 
      HLA class I phenotype. Here, we describe various molecular mechanisms that can 
      lead to HLA total loss or downregulation (phenotype I) in melanoma, colorectal 
      carcinoma and bladder cancer.
FAU - Rodriguez, T
AU  - Rodriguez T
AD  - Servicio de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, 
      Granada, Spain.
FAU - Aptsiauri, N
AU  - Aptsiauri N
FAU - Mendez, R
AU  - Mendez R
FAU - Jimenez, P
AU  - Jimenez P
FAU - Ruiz-Cabello, F
AU  - Ruiz-Cabello F
FAU - Garrido, F
AU  - Garrido F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 2)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 3)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (TAP1 protein, human)
RN  - 145892-13-3 (TAP2 protein, human)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 2
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 3
MH  - ATP-Binding Cassette Transporters/genetics
MH  - Chromosomes, Human, Pair 15/genetics
MH  - Colorectal Neoplasms/*genetics/immunology
MH  - *Down-Regulation
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - *Loss of Heterozygosity
MH  - Melanoma/*genetics/immunology
MH  - Microsatellite Repeats
MH  - Phenotype
MH  - Urinary Bladder Neoplasms/*genetics/immunology
EDAT- 2007/04/21 09:00
MHDA- 2007/06/22 09:00
CRDT- 2007/04/21 09:00
PHST- 2007/04/21 09:00 [pubmed]
PHST- 2007/06/22 09:00 [medline]
PHST- 2007/04/21 09:00 [entrez]
AID - TAN776 [pii]
AID - 10.1111/j.1399-0039.2006.00776.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Apr;69 Suppl 1:259-63. doi: 
      10.1111/j.1399-0039.2006.00776.x.