PMID- 17445221
OWN - NLM
STAT- MEDLINE
DCOM- 20070621
LR  - 20071115
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69 Suppl 1
DP  - 2007 Apr
TI  - 14th International HLA and Immunogenetics Workshop: report from the reproductive 
      immunology component.
PG  - 297-303
AB  - The aim of the study was to investigate whether human leukocyte antigen (HLA) 
      allele sharing between partners or the maternal killer immunoglobulin-like 
      receptor (KIR) repertoire is associated with recurrent spontaneous abortion (RSA) 
      and repeated implantation failure after in vitro fertilization (IVF)/embryo 
      transfer. From a total population of 158 RSA couples, 40 couples with repeated 
      implantation failures (IVF) and 81 control couples, reported by five different 
      laboratories, analysis was performed for (a) HLA sharing in 50 RSA, 31 IVF and 31 
      control couples, (b) DQA1*0505 sharing/homozygosity among partners in 108 RSA, 40 
      IVF and 36 control couples, and (c) the women's KIR repertoire in 46 RSA, 26 IVF 
      and 36 control wives. RSA couples were divided into alloimmune aborter (RSAallo) 
      and autoimmune aborter (RSAauto). The results oppose to the suggestion that 
      increased HLA sharing per se or a limited maternal KIR repertoire predisposes to 
      RSA or IVF failure. However, the observation of a slightly higher percentage of 
      DQA1*0505 sharing in the RSAauto and the IVF group needs further investigation. 
      The ratio of inhibitory to activating KIR (actKIR) was slightly lower in RSAallo 
      and IVF women (1.9 vs 2.6 in controls), while in a high percentage of these 
      women, the standard receptors of the KIR A haplotype were combined with actKIR/s 
      of the haplotype B (66.6% and 45.4% vs 20% and 15.3% in RSAauto and control 
      groups). This may suggest a possible involvement of actKIRs in embryo 
      implantation and the maintenance of pregnancy and also requires further 
      investigation.
FAU - Varla-Leftherioti, M
AU  - Varla-Leftherioti M
AD  - Immunobiology Department, RSA Clinic, Helena Venizelou Maternity Hospital, 
      Athens, Greece. gr1bmdr@hol.gr
FAU - Keramitsoglou, T
AU  - Keramitsoglou T
FAU - Spyropoulou-Vlachou, M
AU  - Spyropoulou-Vlachou M
FAU - Papadimitropoulos, M
AU  - Papadimitropoulos M
FAU - Kontopoulou-Antonopoulou, V
AU  - Kontopoulou-Antonopoulou V
FAU - Tsekoura, C
AU  - Tsekoura C
FAU - Sankarkumar, U
AU  - Sankarkumar U
FAU - Paparistidis, N
AU  - Paparistidis N
FAU - Ghosh, K
AU  - Ghosh K
FAU - Pawar, A
AU  - Pawar A
FAU - Vrani, V
AU  - Vrani V
FAU - Daniilidis, M
AU  - Daniilidis M
FAU - Parapanissiou, E
AU  - Parapanissiou E
FAU - Diler, A S
AU  - Diler AS
FAU - Carin, M
AU  - Carin M
FAU - Stavropoulos-Giokas, C
AU  - Stavropoulos-Giokas C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Abortion, Habitual/blood/genetics/*immunology
MH  - Abortion, Spontaneous/blood/genetics/*immunology
MH  - Embryo Implantation
MH  - Female
MH  - Fertilization in Vitro
MH  - Genotype
MH  - HLA Antigens/*genetics/immunology/metabolism
MH  - Humans
MH  - Immunogenetics
MH  - Killer Cells, Natural/cytology/immunology/*metabolism
MH  - Male
MH  - Polymerase Chain Reaction/methods
MH  - Pregnancy
MH  - Receptors, Immunologic/*genetics/immunology/metabolism
MH  - Receptors, KIR
MH  - Reproduction/*immunology
EDAT- 2007/04/21 09:00
MHDA- 2007/06/22 09:00
CRDT- 2007/04/21 09:00
PHST- 2007/04/21 09:00 [pubmed]
PHST- 2007/06/22 09:00 [medline]
PHST- 2007/04/21 09:00 [entrez]
AID - TAN782 [pii]
AID - 10.1111/j.1399-0039.2006.00782.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Apr;69 Suppl 1:297-303. doi: 
      10.1111/j.1399-0039.2006.00782.x.