PMID- 17445222
OWN - NLM
STAT- MEDLINE
DCOM- 20070621
LR  - 20070420
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69 Suppl 1
DP  - 2007 Apr
TI  - 14th International HLA and Immunogenetics Workshop: report on the immunogenetics 
      of aging.
PG  - 304-10
AB  - The 'Immunogenetics of Aging' is a newly included component within the 14th 
      International HLA and Immunogenetics Workshop. The aim of this component was to 
      determine the contribution of human leukocyte antigen (HLA), cytokine genes and 
      other major histocompatibility complex-encoded loci to successful aging and to 
      determine an increased capacity to reach the extreme limits of life span. Two 
      main data sets from four European populations were included in this study: 
      unrelated healthy elderly individuals and ethnically matched young controls, and 
      families with longevity members. Analysis was focused on HLA class I and II and 
      cytokine gene polymorphisms. Preliminary results showed increased frequencies of 
      DRB1*11- and DRB*16-associated haplotypes that were found to be protective for 
      autoimmune diseases in some populations. Additionally, in families with longevity 
      members, alleles and haplotypes positively associated with autoimmunity were not 
      observed. Analysis of cytokine gene polymorphisms showed prevalence of 
      anti-inflammatory profiles in healthy elderly individuals. Inheritance of 
      extended haplotypes in families with longevity members allowed the identification 
      of immunogenetic profiles that could be predictive for longevity. These 
      preliminary studies indicate the relevance of genes regulating immune functions 
      in human longevity and the importance of clarifying further their impact in 
      successful aging.
FAU - Naumova, E
AU  - Naumova E
AD  - Central Laboratory of Clinical Immunology, University Hospital Alexandrovska, 
      Sofia, Bulgaria. immun@alexandrovska-hospital.bg
FAU - Pawelec, G
AU  - Pawelec G
FAU - Ivanova, M
AU  - Ivanova M
FAU - Constantinescu, I
AU  - Constantinescu I
FAU - Bogunia-Kubik, K
AU  - Bogunia-Kubik K
FAU - Lange, A
AU  - Lange A
FAU - Qguz, F
AU  - Qguz F
FAU - Carin, M
AU  - Carin M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Aging/genetics/immunology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/genetics/*immunology
MH  - Haplotypes/genetics
MH  - Humans
MH  - *Immunogenetics
MH  - Longevity/genetics/*immunology
MH  - Major Histocompatibility Complex/genetics/*immunology
MH  - Male
MH  - Middle Aged
MH  - Pedigree
MH  - Polymorphism, Genetic
EDAT- 2007/04/21 09:00
MHDA- 2007/06/22 09:00
CRDT- 2007/04/21 09:00
PHST- 2007/04/21 09:00 [pubmed]
PHST- 2007/06/22 09:00 [medline]
PHST- 2007/04/21 09:00 [entrez]
AID - TAN783 [pii]
AID - 10.1111/j.1399-0039.2006.00783.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Apr;69 Suppl 1:304-10. doi: 
      10.1111/j.1399-0039.2006.00783.x.