PMID- 17445545
OWN - NLM
STAT- MEDLINE
DCOM- 20070524
LR  - 20131121
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 56
IP  - 5
DP  - 2007 May
TI  - Adipokine levels and cardiovascular risk in patients with adrenal incidentaloma.
PG  - 686-92
AB  - Adrenal incidentalomas (AIs) have been associated with an increased incidence of 
      several cardiovascular risk factors, similar to overt Cushing syndrome. Data 
      about the involvement of the adipokines in the development of insulin resistance 
      and atherosclerosis in AI are completely lacking. The aim of the present study 
      was to evaluate plasma interleukin 6 (IL-6), adiponectin, resistin, tumor 
      necrosis factor alpha (TNF-alpha), and monocyte chemoattractant protein 1 (MCP-1) 
      levels in patients with AI. Plasma IL-6, adiponectin, resistin, TNF-alpha, and 
      MCP-1 levels were measured in 20 healthy subjects (6 males; 14 females; age, 58.5 
      +/- 2.2 years; body mass index, 28.1 +/- 0.9 kg/m(2)) and in 20 patients (5 
      males; 15 females; age, 57.9 +/- 2.0 years; body mass index, 28.0 +/- 0.8 
      kg/m(2)) with AI and typical computed tomographic features of cortical adenoma, 
      who were not affected by diabetes mellitus, hypertension, or other relevant 
      diseases. All patients underwent anthropometric measurements and determination of 
      basal corticotropin, cortisol, and urinary free cortisol excretion. Overnight 
      dexamethasone test and 250-microg corticotropin test were performed in all cases. 
      A subclinical Cushing syndrome was found in 3 patients, whereas the others had 
      apparently nonfunctioning masses. Plasma IL-6, adiponectin, resistin, TNF-alpha, 
      and MCP-1 levels were higher in patients than in controls (64.4 +/- 2.8 vs 5.5 
      +/- 0.6 pg/mL, 13.7 +/- 1.3 vs 3.6 +/- 0.5 microg/mL, 12.5 +/- 1.9 vs 5.1 +/- 0.2 
      ng/mL, 27.0 +/- 1.5 vs 22.2 +/- 1.5 pg/mL, 172.5 +/- 20.0 vs 104.4 +/- 19.5 
      pg/mL, respectively; P < .05) and apparently not affected by the presence of 
      visceral obesity. Plasma IL-6 levels were negatively correlated with urinary free 
      cortisol (r = -0.461, P < .05), and TNF-alpha levels were positively correlated 
      with cortisol after the administration of 1 mg dexamethasone (r = 0.636, P < 
      .01). In conclusion, patients with AI may show increased levels of adipokines 
      (apparently not related to the presence of diabetes, hypertension, or obesity), 
      which may be affected by the presence of the adrenal adenoma. For some 
      adipokines, a direct production from the adrenal gland may be hypothesized even 
      if other studies are needed to better investigate the role of adipokines in 
      states of altered cortisol secretion.
FAU - Ermetici, Federica
AU  - Ermetici F
AD  - Department of Medical and Surgical Sciences, Endocrinology Unit, IRCCS 
      Policlinico San Donato, University of Milano, 20097 San Donato Milanese, Milano, 
      Italy.
FAU - Malavazos, Alexis E
AU  - Malavazos AE
FAU - Corbetta, Sabrina
AU  - Corbetta S
FAU - Morricone, Lelio
AU  - Morricone L
FAU - Dall'Asta, Chiara
AU  - Dall'Asta C
FAU - Corsi, Massimiliano M
AU  - Corsi MM
FAU - Ambrosi, Bruno
AU  - Ambrosi B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Glucocorticoids)
RN  - 0 (Interleukin-6)
RN  - 0 (RETN protein, human)
RN  - 0 (Resistin)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adiponectin/blood
MH  - Adrenal Cortex Neoplasms/*blood/urine
MH  - Adrenocortical Adenoma/*blood/urine
MH  - Adrenocorticotropic Hormone/blood
MH  - Atherosclerosis/*blood/urine
MH  - Chemokine CCL2/blood
MH  - Dexamethasone/pharmacology
MH  - Female
MH  - Glucocorticoids/pharmacology
MH  - Humans
MH  - Hydrocortisone/blood/urine
MH  - Interleukin-6/blood
MH  - Male
MH  - Middle Aged
MH  - Resistin/blood
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2007/04/21 09:00
MHDA- 2007/05/26 09:00
CRDT- 2007/04/21 09:00
PHST- 2006/07/18 00:00 [received]
PHST- 2006/12/11 00:00 [accepted]
PHST- 2007/04/21 09:00 [pubmed]
PHST- 2007/05/26 09:00 [medline]
PHST- 2007/04/21 09:00 [entrez]
AID - S0026-0495(07)00042-X [pii]
AID - 10.1016/j.metabol.2006.12.018 [doi]
PST - ppublish
SO  - Metabolism. 2007 May;56(5):686-92. doi: 10.1016/j.metabol.2006.12.018.