PMID- 17445656
OWN - NLM
STAT- MEDLINE
DCOM- 20070524
LR  - 20131121
IS  - 1527-9995 (Electronic)
IS  - 0090-4295 (Linking)
VI  - 69
IP  - 4
DP  - 2007 Apr
TI  - Serum sex steroid hormones and lower urinary tract symptoms in Third National 
      Health and Nutrition Examination Survey (NHANES III).
PG  - 708-13
AB  - OBJECTIVES: To evaluate the association of circulating sex steroid hormones and 
      sex hormone binding globulin (SHBG) with lower urinary tract symptoms (LUTS). 
      METHODS: We included 260 men, 60 years old or older, who participated in Phase 1 
      (1988 to 1991) of the Third National Health and Nutrition Examination Survey and 
      for whom surplus serum was available. We measured the serum concentrations of 
      testosterone, androstanediol glucuronide (AAG), estradiol, and SHBG. Free 
      testosterone was calculated from the circulating testosterone, SHBG, and albumin. 
      The cases (n = 128) were men with two to four symptoms (nocturia, hesitancy, 
      incomplete emptying, and weak stream), but who had never undergone noncancer 
      prostate surgery. The controls (n = 132) were men who neither had symptoms nor 
      had undergone noncancer prostate surgery. We adjusted for age, race/ethnicity, 
      waist circumference, cigarette smoking, alcohol consumption, and physical 
      activity in logistic regression models and used sampling weights. RESULTS: The 
      cases had statistically significantly greater AAG and estradiol concentrations 
      than did the controls. After multivariate adjustment, the men in the top tertile 
      of AAG (odds ratio 2.62, 95% confidence interval 1.12 to 6.14) had a greater risk 
      of LUTS compared with men in the bottom two tertiles. Also, men with a greater 
      estradiol concentration (odds ratio 1.78, 95% confidence interval 0.91 to 3.49) 
      and a greater estradiol/SHBG molar ratio (odds ratio 2.41, 95% confidence 
      interval 1.39 to 4.17) had a greater risk of LUTS than did men with lower 
      concentrations. No consistent associations were seen for circulating 
      testosterone, free testosterone, or SHBG. CONCLUSIONS: In this cross-sectional 
      study representative of older U.S. men, circulating AAG, a metabolite of 
      dihydrotestosterone, and estradiol were associated with an increased risk of 
      having LUTS.
FAU - Rohrmann, Sabine
AU  - Rohrmann S
AD  - Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, 
      Germany.
FAU - Nelson, William G
AU  - Nelson WG
FAU - Rifai, Nader
AU  - Rifai N
FAU - Kanarek, Norma
AU  - Kanarek N
FAU - Basaria, Shehzad
AU  - Basaria S
FAU - Tsilidis, Konstantinos K
AU  - Tsilidis KK
FAU - Smit, Ellen
AU  - Smit E
FAU - Giovannucci, Edward
AU  - Giovannucci E
FAU - Platz, Elizabeth A
AU  - Platz EA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Urology
JT  - Urology
JID - 0366151
RN  - 0 (Sex Hormone-Binding Globulin)
RN  - 25126-76-5 (Androstane-3,17-diol)
RN  - 27195-25-1 (androstane-3,17-diol glucuronide)
RN  - 3XMK78S47O (Testosterone)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Androstane-3,17-diol/*analogs & derivatives/blood
MH  - Cross-Sectional Studies
MH  - Estradiol/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prostatism/*blood
MH  - Sex Hormone-Binding Globulin/*analysis
MH  - Testosterone/*blood
EDAT- 2007/04/21 09:00
MHDA- 2007/05/26 09:00
CRDT- 2007/04/21 09:00
PHST- 2006/07/19 00:00 [received]
PHST- 2006/10/09 00:00 [revised]
PHST- 2007/01/05 00:00 [accepted]
PHST- 2007/04/21 09:00 [pubmed]
PHST- 2007/05/26 09:00 [medline]
PHST- 2007/04/21 09:00 [entrez]
AID - S0090-4295(07)00012-X [pii]
AID - 10.1016/j.urology.2007.01.011 [doi]
PST - ppublish
SO  - Urology. 2007 Apr;69(4):708-13. doi: 10.1016/j.urology.2007.01.011.