PMID- 17445988
OWN - NLM
STAT- MEDLINE
DCOM- 20071025
LR  - 20220309
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 146
IP  - 4
DP  - 2007 Jun 8
TI  - Opposing effects of intra-nucleus accumbens mu and kappa opioid agonists on 
      sensory specific satiety.
PG  - 1445-52
AB  - Mu opioid (MOP) agonists acting in the nucleus accumbens (NAcc) robustly enhance 
      consumption of palatable foods. In addition, the effect on consumption of 
      palatable foods produced by MOP agonists acting in the NAcc depends on both 
      recent flavor exposure and the availability of a choice between 
      different-flavored foods. In contrast, kappa opioid (KOP) agonists have variable 
      effects on feeding and KOP agonists have MOP opposing behavioral actions when 
      microinjected at several brain sites. We previously demonstrated that NAcc MOP 
      agonists reverse the devaluation (satiety) effect of pre-feeding for a given 
      flavor; in fact, NAcc MOP agonists selectively increase consumption of a recently 
      sampled food. In contrast, in the present study, we found that the selective KOP 
      agonist U50488 injected into the NAcc of rats reduced consumption of a recently 
      sampled flavor while increasing consumption of the flavor that was not pre-fed. 
      Intra-NAcc U50488 did not affect overall consumption or flavor preference in the 
      absence of pre-feeding. The present data, in conjunction with our previous 
      findings, highlight the robust and opposing role of NAcc MOP and KOP opioid 
      receptors in palatability-based food choice and consumption and raise the 
      possibility that an endogenous KOP agonist acting in the NAcc contributes to the 
      phenomenon of sensory specific satiety.
FAU - Woolley, J D
AU  - Woolley JD
AD  - The Ernest Gallo Clinic and Research Center and the Wheeler Center for the 
      Neurobiology of Addiction, Department of Neurology, University of California, San 
      Francisco, San Francisco, CA 94143, USA. jwoolley@memory.ucsf.edu
FAU - Lee, B S
AU  - Lee BS
FAU - Kim, B
AU  - Kim B
FAU - Fields, H L
AU  - Fields HL
LA  - eng
PT  - Journal Article
DEP - 20070419
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Analgesics)
RN  - 0 (Receptors, Opioid, kappa)
RN  - 0 (Receptors, Opioid, mu)
SB  - IM
MH  - Analgesics/*pharmacology
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal
MH  - Food Preferences/drug effects
MH  - Male
MH  - Nucleus Accumbens/*drug effects
MH  - Rats
MH  - Rats, Long-Evans
MH  - Receptors, Opioid, kappa/*agonists/physiology
MH  - Receptors, Opioid, mu/*agonists/physiology
MH  - Satiety Response/*drug effects
MH  - Taste
MH  - Time Factors
EDAT- 2007/04/21 09:00
MHDA- 2007/10/27 09:00
CRDT- 2007/04/21 09:00
PHST- 2007/01/11 00:00 [received]
PHST- 2007/03/02 00:00 [revised]
PHST- 2007/03/07 00:00 [accepted]
PHST- 2007/04/21 09:00 [pubmed]
PHST- 2007/10/27 09:00 [medline]
PHST- 2007/04/21 09:00 [entrez]
AID - S0306-4522(07)00318-1 [pii]
AID - 10.1016/j.neuroscience.2007.03.012 [doi]
PST - ppublish
SO  - Neuroscience. 2007 Jun 8;146(4):1445-52. doi: 10.1016/j.neuroscience.2007.03.012. 
      Epub 2007 Apr 19.