PMID- 17446338
OWN - NLM
STAT- MEDLINE
DCOM- 20071005
LR  - 20131121
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 176
IP  - 4
DP  - 2007 Aug 15
TI  - Lung function growth in children with long-term exposure to air pollutants in 
      Mexico City.
PG  - 377-84
AB  - RATIONALE: Although short-term exposure to air pollution has been associated with 
      acute, reversible lung function decrements, the impact of long-term exposure has 
      not been well established. OBJECTIVES: To evaluate the association between 
      long-term exposure to ozone (O(3)), particulate matter less than 10 mum in 
      diameter (PM(10)), and nitrogen dioxide (NO(2)) and lung function growth in 
      Mexico City schoolchildren. METHODS: A dynamic cohort of 3,170 children aged 8 
      years at baseline was followed from April 23, 1996, through May 19, 1999. The 
      children attended 39 randomly selected elementary schools located near 10 air 
      quality monitoring stations and were visited every 6 months. Statistical analyses 
      were performed using general linear mixed models. MEASUREMENTS AND MAIN RESULTS: 
      After adjusting for acute exposure and other potential confounding factors, 
      deficits in FVC and FEV(1) growth over the 3-year follow-up period were 
      significantly associated with exposure to O(3), PM(10), and NO(2). In 
      multipollutant models, an interquartile range (IQR) increase in mean O(3) 
      concentration (IQR, 11.3 ppb) was associated with an annual deficit in FEV(1) of 
      12 ml in girls and 4 ml in boys, an IQR range (IQR, 36.4 microg/m(3)) increase in 
      PM(10) with an annual deficit in FEV(1) of 11 ml in girls and 15 ml in boys, and 
      an IQR range (IQR, 12.0 ppb) increase in NO(2) with an annual deficit in FEV(1) 
      of 30 ml in girls and 25 ml in boys. CONCLUSIONS: We conclude that long-term 
      exposure to O(3), PM(10), and NO(2) is associated with a deficit in FVC and 
      FEV(1) growth among schoolchildren living in Mexico City.
FAU - Rojas-Martinez, Rosalba
AU  - Rojas-Martinez R
AD  - Instituto Nacional de Salud Publica, 655 Avenida Universidad, Col. Santa Maria 
      Ahuacatitlan, Cuernavaca, Morelos 62508, Mexico.
FAU - Perez-Padilla, Rogelio
AU  - Perez-Padilla R
FAU - Olaiz-Fernandez, Gustavo
AU  - Olaiz-Fernandez G
FAU - Mendoza-Alvarado, Laura
AU  - Mendoza-Alvarado L
FAU - Moreno-Macias, Hortensia
AU  - Moreno-Macias H
FAU - Fortoul, Teresa
AU  - Fortoul T
FAU - McDonnell, William
AU  - McDonnell W
FAU - Loomis, Dana
AU  - Loomis D
FAU - Romieu, Isabelle
AU  - Romieu I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20070419
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Air Pollutants)
RN  - 66H7ZZK23N (Ozone)
RN  - S7G510RUBH (Nitrogen Dioxide)
SB  - IM
MH  - Air Pollutants/adverse effects/chemistry
MH  - Air Pollution/*adverse effects
MH  - Child
MH  - Environmental Exposure/*adverse effects
MH  - Environmental Monitoring
MH  - Female
MH  - Follow-Up Studies
MH  - Forced Expiratory Flow Rates/*physiology
MH  - Forced Expiratory Volume/*physiology
MH  - Humans
MH  - Lung/*physiopathology
MH  - Male
MH  - Mexico
MH  - Nitrogen Dioxide/adverse effects/analysis
MH  - Ozone/adverse effects/analysis
MH  - Particle Size
MH  - Prospective Studies
EDAT- 2007/04/21 09:00
MHDA- 2007/10/06 09:00
CRDT- 2007/04/21 09:00
PHST- 2007/04/21 09:00 [pubmed]
PHST- 2007/10/06 09:00 [medline]
PHST- 2007/04/21 09:00 [entrez]
AID - 200510-1678OC [pii]
AID - 10.1164/rccm.200510-1678OC [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2007 Aug 15;176(4):377-84. doi: 
      10.1164/rccm.200510-1678OC. Epub 2007 Apr 19.