PMID- 17446729
OWN - NLM
STAT- MEDLINE
DCOM- 20070612
LR  - 20221207
IS  - 1594-0667 (Print)
IS  - 1594-0667 (Linking)
VI  - 19
IP  - 2
DP  - 2007 Apr
TI  - Estrogen Receptor 1 gene (ESR1) variants in Alzheimer's disease. Results of a 
      meta-analysis.
PG  - 165-8
AB  - BACKGROUND AND AIMS: There is some disagreement between clinical and basic 
      science as to the benefit of estrogen in preventing cognitive decline. For 
      cardiovascular disease, estrogen effects have been shown to vary with estrogen 
      receptor (ESR) genotype. The present study was conceived to review evidence of 
      ESR association with Alzheimer's disease (AD) which could account for the 
      variability observed in estrogen treatment outcome. METHODS: A meta-analysis was 
      performed on data from 8288 cases and controls, controlling for ethnicity (Asian 
      vs European). To explore the specificity of our findings further, a second 
      meta-analysis of association studies was then appended, addressing non-AD forms 
      of dementia or cognitive impairment (total n=11036). RESULTS: A significant 
      overall association of AD with two neighboring ESR1 variants located in a 
      transcription-enhancing region (p=0.015) was noted. The genotypic effect was 
      driven by the minor alleles in Asian populations, and did not reach significance 
      in European samples (OR=1.1, p>0.267). When the phenotype was extended to other 
      forms of dementia or cognitive impairment, the association was no longer 
      observed. CONCLUSIONS: ESR1 variability was confirmed to modulate susceptibility 
      to AD in Asian individuals, but not in Europeans. More research is required to 
      address possible clinical implications, e.g., for hormone replacement therapy in 
      early stages of AD.
FAU - Luckhaus, Christian
AU  - Luckhaus C
AD  - Department of Psychiatry, University of Duesseldorf, Duesseldorf, Germany.
FAU - Sand, Philipp G
AU  - Sand PG
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - Germany
TA  - Aging Clin Exp Res
JT  - Aging clinical and experimental research
JID - 101132995
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*genetics
MH  - Asian People
MH  - Estrogen Receptor alpha/*genetics
MH  - Humans
MH  - Polymorphism, Genetic
MH  - White People
EDAT- 2007/04/21 09:00
MHDA- 2007/06/15 09:00
CRDT- 2007/04/21 09:00
PHST- 2007/04/21 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2007/04/21 09:00 [entrez]
AID - 3547 [pii]
AID - 10.1007/BF03324684 [doi]
PST - ppublish
SO  - Aging Clin Exp Res. 2007 Apr;19(2):165-8. doi: 10.1007/BF03324684.